Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J

Abstract A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents Aβ1–42 induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by Aβ1–42 . This beneficial and multi-faceted mode of action of the ginkgolide makes it a new and promising lead in designing therapies against Alzheimer's disease.