Effects of Prandial Versus Fasting Glycemia on Cardiovascular Outcomes in Type 2 Diabetes: The HEART2D trial

OBJECTIVE:--Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control on risk for cardiovas...

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Veröffentlicht in:	Diabetes care 2009-03, Vol.32 (3), p.381-386
Hauptverfasser:	Raz, Itamar, Wilson, Peter W.F, Strojek, Krzysztof, Kowalska, Irina, Bozikov, Velimir, Gitt, Anselm K, Jermendy, György, Campaigne, Barbara N, Kerr, Lisa, Milicevic, Zvonko, Jacober, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Blood sugar Body Weight - drug effects Cardiac patients Cardiovascular System - drug effects Cardiovascular System - metabolism Cholesterol Clinical Care/Education/Nutrition/Psychosocial Research Clinical trials Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes therapy Diabetes. Impaired glucose tolerance Diabetics Drug Administration Schedule Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Female Heart attack Heart attacks Humans Hyperglycemia Hypoglycemic Agents - adverse effects Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin Insulin - adverse effects Insulin - analogs & derivatives Insulin - therapeutic use Insulin Glargine Insulin Lispro Insulin, Long-Acting Male Medical research Medical sciences Medicine, Experimental Metabolic diseases Middle Aged Miscellaneous Mortality Patient outcomes Pharmaceutical industry Postprandial Period Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Treatment Outcome Type 2 diabetes
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Zusammenfassung:	OBJECTIVE:--Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control on risk for cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction (AMI). RESEARCH DESIGN AND METHODS--Patients (type 2 diabetes, aged 30-75 years) were randomly assigned within 21 days after AMI to the 1) prandial strategy (PRANDIAL) (three premeal doses of insulin lispro targeting 2-h postprandial blood glucose
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc08-1671