The cyclic AMP phenotype of fragile X and autism

Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cA...

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Veröffentlicht in:	Neuroscience and biobehavioral reviews 2008-10, Vol.32 (8), p.1533-1543
Hauptverfasser:	Kelley, Daniel J., Bhattacharyya, Anita, Lahvis, Garet P., Yin, Jerry C.P., Malter, Jim, Davidson, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - metabolism Autism Autistic Disorder - complications Autistic Disorder - genetics Autistic Disorder - metabolism Behavioral psychophysiology Biological and medical sciences cAMP Child clinical studies Cyclic AMP Cyclic AMP - metabolism Developmental disorders FMR1 FMRP Fragile X Fragile X Mental Retardation Protein - genetics Fragile X Syndrome - complications Fragile X Syndrome - genetics Fragile X Syndrome - metabolism Fundamental and applied biological sciences. Psychology Humans Infantile autism Medical sciences Memory - physiology Models, Biological Phenotype Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Signal transduction
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Zusammenfassung:	Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.
ISSN:	0149-7634 1873-7528
DOI:	10.1016/j.neubiorev.2008.06.005