The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay
Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA Correspondence Özlem Yilmaz oyilmaz{at}ufl.edu The microbiota of the human oral mucosa consists of a myriad of bacterial species that normally exist in commensal har...
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Veröffentlicht in: | Microbiology (Society for General Microbiology) 2008-10, Vol.154 (10), p.2897-2903 |
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description | Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
Correspondence Özlem Yilmaz oyilmaz{at}ufl.edu
The microbiota of the human oral mucosa consists of a myriad of bacterial species that normally exist in commensal harmony with the host. Porphyromonas gingivalis , an aetiological agent in severe forms of periodontitis (a chronic inflammatory disease), is a prominent component of the oral microbiome and a successful colonizer of the oral epithelium. This Gram-negative anaerobe can also exist within the host epithelium without the existence of overt disease. Gingival epithelial cells, the outer lining of the gingival mucosa, which function as an important part of the innate immune system, are among the first host cells colonized by P. gingivalis . This review describes recent studies implicating the co-existence and intracellular adaptation of the organism in these target host cells. Specifically, recent findings on the putative mechanisms of persistence, intercellular dissemination and opportunism are highlighted. These new findings may also represent an original and valuable model for mechanistic characterization of other successful host-adapted, self-limiting, persistent intracellular bacteria in human epithelial tissues. |
doi_str_mv | 10.1099/mic.0.2008/021220-0 |
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Correspondence Özlem Yilmaz oyilmaz{at}ufl.edu
The microbiota of the human oral mucosa consists of a myriad of bacterial species that normally exist in commensal harmony with the host. Porphyromonas gingivalis , an aetiological agent in severe forms of periodontitis (a chronic inflammatory disease), is a prominent component of the oral microbiome and a successful colonizer of the oral epithelium. This Gram-negative anaerobe can also exist within the host epithelium without the existence of overt disease. Gingival epithelial cells, the outer lining of the gingival mucosa, which function as an important part of the innate immune system, are among the first host cells colonized by P. gingivalis . This review describes recent studies implicating the co-existence and intracellular adaptation of the organism in these target host cells. Specifically, recent findings on the putative mechanisms of persistence, intercellular dissemination and opportunism are highlighted. These new findings may also represent an original and valuable model for mechanistic characterization of other successful host-adapted, self-limiting, persistent intracellular bacteria in human epithelial tissues.</description><identifier>ISSN: 1350-0872</identifier><identifier>EISSN: 1465-2080</identifier><identifier>DOI: 10.1099/mic.0.2008/021220-0</identifier><identifier>PMID: 18832296</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Adaptation, Physiological ; Bacteriology ; Bacteroidaceae Infections - immunology ; Bacteroidaceae Infections - microbiology ; Biological and medical sciences ; Epithelium - immunology ; Epithelium - microbiology ; Fundamental and applied biological sciences. Psychology ; Gingiva - immunology ; Gingiva - microbiology ; Host-Pathogen Interactions ; Humans ; Microbiology ; Mouth Mucosa - immunology ; Mouth Mucosa - microbiology ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Periodontitis - immunology ; Periodontitis - microbiology ; Porphyromonas gingivalis ; Porphyromonas gingivalis - immunology ; Porphyromonas gingivalis - pathogenicity</subject><ispartof>Microbiology (Society for General Microbiology), 2008-10, Vol.154 (10), p.2897-2903</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4140-929fb3864bf008b7b8733f92094a93c51dc5fe4f98ceb72fbc05dd93c154b87b3</citedby><cites>FETCH-LOGICAL-c4140-929fb3864bf008b7b8733f92094a93c51dc5fe4f98ceb72fbc05dd93c154b87b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639765/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639765/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20758933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18832296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Ozlem</creatorcontrib><title>The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay</title><title>Microbiology (Society for General Microbiology)</title><addtitle>Microbiology</addtitle><description>Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
Correspondence Özlem Yilmaz oyilmaz{at}ufl.edu
The microbiota of the human oral mucosa consists of a myriad of bacterial species that normally exist in commensal harmony with the host. Porphyromonas gingivalis , an aetiological agent in severe forms of periodontitis (a chronic inflammatory disease), is a prominent component of the oral microbiome and a successful colonizer of the oral epithelium. This Gram-negative anaerobe can also exist within the host epithelium without the existence of overt disease. Gingival epithelial cells, the outer lining of the gingival mucosa, which function as an important part of the innate immune system, are among the first host cells colonized by P. gingivalis . This review describes recent studies implicating the co-existence and intracellular adaptation of the organism in these target host cells. Specifically, recent findings on the putative mechanisms of persistence, intercellular dissemination and opportunism are highlighted. These new findings may also represent an original and valuable model for mechanistic characterization of other successful host-adapted, self-limiting, persistent intracellular bacteria in human epithelial tissues.</description><subject>Adaptation, Physiological</subject><subject>Bacteriology</subject><subject>Bacteroidaceae Infections - immunology</subject><subject>Bacteroidaceae Infections - microbiology</subject><subject>Biological and medical sciences</subject><subject>Epithelium - immunology</subject><subject>Epithelium - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gingiva - immunology</subject><subject>Gingiva - microbiology</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Mouth Mucosa - immunology</subject><subject>Mouth Mucosa - microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Periodontitis - immunology</subject><subject>Periodontitis - microbiology</subject><subject>Porphyromonas gingivalis</subject><subject>Porphyromonas gingivalis - immunology</subject><subject>Porphyromonas gingivalis - pathogenicity</subject><issn>1350-0872</issn><issn>1465-2080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P1SAUhhujccbRX2BiutGFsXcOUFqYhYmZ-JVMootxTSiFFtPCFW7H3H_vqbcZdeUKOO9zvniL4jmBHQEpL2dvdrCjAOISKKEUKnhQnJO64RUFAQ_xzjgGRUvPiic5fwdAEcjj4owIwSiVzXkx3o62NGOKwZvJ5jK68mtM-_GY4hyDzuXgw-Dv9OTzVXlAFrum2PllfvP7OS6zDmVMeirt3mNkQqnUoV9Vn0ofDjbtJ318Wjxyesr22XZeFN8-vL-9_lTdfPn4-frdTWVqUkMlqXQdE03dOVysazvRMuYkBVlryQwnveHO1k4KY7uWus4A73tUCK-R7dhF8fZUd790s-2NDQccTu2Tn3U6qqi9-lcJflRDvFO0YbJtOBZ4tRVI8cdi80HNPhs7TTrYuGTVyIZyEPS_IJFt3XIqEWQnEH8u52Td_TQE1GolJhoFarVSnaxUgFkv_l7kT87mHQIvN0BnoyeXdDA-33MUWi4kY8i9PnGjH8afPlk12LDZGNfW-HXrJFTIlv0CLfu4oQ</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Yilmaz, Ozlem</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081001</creationdate><title>The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay</title><author>Yilmaz, Ozlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4140-929fb3864bf008b7b8733f92094a93c51dc5fe4f98ceb72fbc05dd93c154b87b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adaptation, Physiological</topic><topic>Bacteriology</topic><topic>Bacteroidaceae Infections - immunology</topic><topic>Bacteroidaceae Infections - microbiology</topic><topic>Biological and medical sciences</topic><topic>Epithelium - immunology</topic><topic>Epithelium - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gingiva - immunology</topic><topic>Gingiva - microbiology</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Microbiology</topic><topic>Mouth Mucosa - immunology</topic><topic>Mouth Mucosa - microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Periodontitis - immunology</topic><topic>Periodontitis - microbiology</topic><topic>Porphyromonas gingivalis</topic><topic>Porphyromonas gingivalis - immunology</topic><topic>Porphyromonas gingivalis - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz, Ozlem</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microbiology (Society for General Microbiology)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz, Ozlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay</atitle><jtitle>Microbiology (Society for General Microbiology)</jtitle><addtitle>Microbiology</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>154</volume><issue>10</issue><spage>2897</spage><epage>2903</epage><pages>2897-2903</pages><issn>1350-0872</issn><eissn>1465-2080</eissn><abstract>Department of Periodontology, College of Dentistry and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
Correspondence Özlem Yilmaz oyilmaz{at}ufl.edu
The microbiota of the human oral mucosa consists of a myriad of bacterial species that normally exist in commensal harmony with the host. Porphyromonas gingivalis , an aetiological agent in severe forms of periodontitis (a chronic inflammatory disease), is a prominent component of the oral microbiome and a successful colonizer of the oral epithelium. This Gram-negative anaerobe can also exist within the host epithelium without the existence of overt disease. Gingival epithelial cells, the outer lining of the gingival mucosa, which function as an important part of the innate immune system, are among the first host cells colonized by P. gingivalis . This review describes recent studies implicating the co-existence and intracellular adaptation of the organism in these target host cells. Specifically, recent findings on the putative mechanisms of persistence, intercellular dissemination and opportunism are highlighted. These new findings may also represent an original and valuable model for mechanistic characterization of other successful host-adapted, self-limiting, persistent intracellular bacteria in human epithelial tissues.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>18832296</pmid><doi>10.1099/mic.0.2008/021220-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adaptation, Physiological Bacteriology Bacteroidaceae Infections - immunology Bacteroidaceae Infections - microbiology Biological and medical sciences Epithelium - immunology Epithelium - microbiology Fundamental and applied biological sciences. Psychology Gingiva - immunology Gingiva - microbiology Host-Pathogen Interactions Humans Microbiology Mouth Mucosa - immunology Mouth Mucosa - microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Periodontitis - immunology Periodontitis - microbiology Porphyromonas gingivalis Porphyromonas gingivalis - immunology Porphyromonas gingivalis - pathogenicity |
title | The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay |
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