Synthetic Studies Towards Mannopeptimycin-E: Synthesis of the

The enantioselective synthesis of the C -4′ acylated 1,4-α,α- manno,manno -disaccharide fragment of mannopeptimycin-E has been achieved in 7 steps from D-tyrosine. The route relies upon diastereoselective palladium-catalyzed glycosylation, diastereoselective reduction and diastereoselective bis-dihydroxylation. The efficiency of the synthesis is demonstrated by the high overall yield (37%) and the preparation of various analogues.