Fertility Drug Use and Mammographic Breast Density in a Mammography Screening Cohort of Premenopausal Women

Fertility Drug Use and Mammographic Breast Density in a Mammography Screening Cohort of Premenopausal Women

The widespread use of ovulation-inducing drugs to enhance fertility has raised concerns about its potential effects on breast cancer risk, as ovarian stimulation is associated with increases in estrogen and progesterone levels. We investigated the short-term relation between fertility drug use and m...

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Veröffentlicht in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-11, Vol.17 (11), p.3128-3133
Hauptverfasser: Sprague, Brian L, Trentham-Dietz, Amy, Terry, Mary Beth, Nichols, Hazel B, Bersch, Andrew J, Buist, Diana S M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Analysis of Variance
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - epidemiology
Breast pathology
Chi-Square Distribution
Drug effects
Female
Fertility agents
Fertility Agents, Female - administration & dosage
Humans
Infertility, Female - drug therapy
Logistic Models
Mammography
Middle Aged
Pharmacoepidemiology
Premenopause
Risk Factors
Washington - epidemiology
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Zusammenfassung:The widespread use of ovulation-inducing drugs to enhance fertility has raised concerns about its potential effects on breast cancer risk, as ovarian stimulation is associated with increases in estrogen and progesterone levels. We investigated the short-term relation between fertility drug use and mammographic breast density, a strong marker of breast cancer risk, among participants in the Group Health Breast Cancer Screening Program. Data linkage with Group Health automated pharmacy records identified 104 premenopausal women
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-08-0503