Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset...

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Veröffentlicht in:	Journal of cellular biochemistry 2008-08, Vol.104 (6), p.2016-2026
Hauptverfasser:	Stein, Gary S., Zaidi, Sayyed K., Stein, Janet L., Lian, Jane B., van Wijnen, Andre J., Montecino, Martin, Young, Daniel W., Javed, Amjad, Pratap, Jitesh, Choi, Je-Yong, Ali, Syed A., Pande, Sandhya, Hassan, Mohammad Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - genetics chromatin Epigenesis, Genetic epigenetic control Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Neoplasms - genetics Neoplasms - pathology nuclear matrix nuclear microenvironments transcription Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment. J. Cell. Biochem. 104: 2016–2026, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:	0730-2312 1097-4644
DOI:	10.1002/jcb.21813