trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation
Background and purpose: trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not b...
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| Veröffentlicht in: | British journal of pharmacology 2008-12, Vol.155 (7), p.995-1004 |
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| container_title | British journal of pharmacology |
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| creator | Tan, Y Lim, L H K |
| description | Background and purpose:
trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not been investigated.
Experimental approach:
Human eosinophils were isolated and purified from whole blood and incubated for 16 h with trans‐resveratrol. Eosinophil chemotaxis, activation and degranulation, and apoptosis were investigated. The effect of trans‐resveratrol on the inhibition of p38 and ERK1/2 activation was examined.
Key results:
Treatment of human eosinophils with trans‐resveratrol at concentrations |
| doi_str_mv | 10.1038/bjp.2008.330 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2597253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1600761991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5782-befc25c2128cb8bb638a0a59bd635325f87d4c68c4baf95a984031869cd408473</originalsourceid><addsrcrecordid>eNp9kc9vFCEcxYnR2LV682yIiZ52Vn4MA1yaaGOtSRON0TMBhumyYWGFma29-Sf4N_qXlHU3bfVgOJDwPjy-jwfAc4wWGFHxxqw2C4KQWFCKHoAZbnnXMCrwQzBDCPEGYyGOwJNSVghVkbPH4AgLzjuJ-QzYMetYfv_89cWVrct6zCnMoY7Q_aiKHWEaYHY9vPLRzaGPS2_8WOByWu-YVHxMm6UPsKJ-q0efYr3cw95dVt8p_Dl5Ch4NOhT37LAfg29n77-enjcXnz58PH170VjGBWmMGyxhlmAirBHGdFRopJk0fUcZJWwQvG9tJ2xr9CCZlqJFFItO2r5FouX0GJzsfTeTWbveulgjBLXJfq3ztUraq7-V6JfqMm0VYZITRqvB64NBTt8nV0a19sW6EHR0aSoKSyYZ69oKvvwHXKUpxxpOEcwJYrSVFZrvIZtTKdkNt5NgpHbVqVqd2lWnanUVf3F_-jv40FUFXh0AXawOQ_1g68stR5DkHSG7FHjPXfngrv_7qHr3-ZySum4AprOzZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217205349</pqid></control><display><type>article</type><title>trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Tan, Y ; Lim, L H K</creator><creatorcontrib>Tan, Y ; Lim, L H K</creatorcontrib><description>Background and purpose:
trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not been investigated.
Experimental approach:
Human eosinophils were isolated and purified from whole blood and incubated for 16 h with trans‐resveratrol. Eosinophil chemotaxis, activation and degranulation, and apoptosis were investigated. The effect of trans‐resveratrol on the inhibition of p38 and ERK1/2 activation was examined.
Key results:
Treatment of human eosinophils with trans‐resveratrol at concentrations <100 μM for 16 h did not induce eosinophil apoptosis. Similar results were seen after 24 h and 48 h incubations. trans‐Resveratrol (<100 μM) significantly inhibited eosinophil peroxidase release after activation with IL‐5 (IC50=2.9±0.9 μM) or C5a (IC50=3.9±0.5 μM) after 5 min priming with cytochalasin B (CB). Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans‐resveratrol, at concentrations above 5 μM. All the activators induced p38 and ERK1/2 phosphorylation maximal at 2 min of activation. trans‐Resveratrol potently inhibited p38 and ERK1/2 activation after calcium ionophore and CB and C5a activation.
Conclusions and implications:
trans‐Resveratrol is effective at inhibiting human eosinophil activation and degranulation at concentrations <100 μM, while not inducing apoptosis. This potent anti‐inflammatory activity of trans‐resveratrol and possibly its metabolites on eosinophils may be worth investigating for the treatment of eosinophil‐related allergic diseases.
British Journal of Pharmacology (2008) 155, 995–1004; doi:10.1038/bjp.2008.330; published online 8 September 2008</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/bjp.2008.330</identifier><identifier>PMID: 18776917</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; apoptosis ; Apoptosis - drug effects ; asthma ; Biological and medical sciences ; Cell Degranulation - drug effects ; chemotaxis ; Chemotaxis, Leukocyte - drug effects ; Chronic obstructive pulmonary disease, asthma ; Dose-Response Relationship, Drug ; eosinophil activation ; Eosinophil Peroxidase - drug effects ; Eosinophil Peroxidase - metabolism ; eosinophils ; Eosinophils - drug effects ; Eosinophils - metabolism ; Humans ; Inhibitory Concentration 50 ; Leukotriene C4 - metabolism ; Medical sciences ; Mitogen-Activated Protein Kinase 1 - drug effects ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - drug effects ; Mitogen-Activated Protein Kinase 3 - metabolism ; p38 Mitogen-Activated Protein Kinases - drug effects ; p38 Mitogen-Activated Protein Kinases - metabolism ; Pharmacology. Drug treatments ; Phosphorylation - drug effects ; phytochemical ; Pneumology ; Research Papers ; Stilbenes - administration & dosage ; Stilbenes - pharmacology ; Time Factors ; Vitaceae ; Wine</subject><ispartof>British journal of pharmacology, 2008-12, Vol.155 (7), p.995-1004</ispartof><rights>2008 British Pharmacological Society</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2008</rights><rights>Copyright 2008, Nature Publishing Group 2008 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5782-befc25c2128cb8bb638a0a59bd635325f87d4c68c4baf95a984031869cd408473</citedby><cites>FETCH-LOGICAL-c5782-befc25c2128cb8bb638a0a59bd635325f87d4c68c4baf95a984031869cd408473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597253/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597253/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46388,46812,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20976223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18776917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Y</creatorcontrib><creatorcontrib>Lim, L H K</creatorcontrib><title>trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Background and purpose:
trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not been investigated.
Experimental approach:
Human eosinophils were isolated and purified from whole blood and incubated for 16 h with trans‐resveratrol. Eosinophil chemotaxis, activation and degranulation, and apoptosis were investigated. The effect of trans‐resveratrol on the inhibition of p38 and ERK1/2 activation was examined.
Key results:
Treatment of human eosinophils with trans‐resveratrol at concentrations <100 μM for 16 h did not induce eosinophil apoptosis. Similar results were seen after 24 h and 48 h incubations. trans‐Resveratrol (<100 μM) significantly inhibited eosinophil peroxidase release after activation with IL‐5 (IC50=2.9±0.9 μM) or C5a (IC50=3.9±0.5 μM) after 5 min priming with cytochalasin B (CB). Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans‐resveratrol, at concentrations above 5 μM. All the activators induced p38 and ERK1/2 phosphorylation maximal at 2 min of activation. trans‐Resveratrol potently inhibited p38 and ERK1/2 activation after calcium ionophore and CB and C5a activation.
Conclusions and implications:
trans‐Resveratrol is effective at inhibiting human eosinophil activation and degranulation at concentrations <100 μM, while not inducing apoptosis. This potent anti‐inflammatory activity of trans‐resveratrol and possibly its metabolites on eosinophils may be worth investigating for the treatment of eosinophil‐related allergic diseases.
British Journal of Pharmacology (2008) 155, 995–1004; doi:10.1038/bjp.2008.330; published online 8 September 2008</description><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>asthma</subject><subject>Biological and medical sciences</subject><subject>Cell Degranulation - drug effects</subject><subject>chemotaxis</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Dose-Response Relationship, Drug</subject><subject>eosinophil activation</subject><subject>Eosinophil Peroxidase - drug effects</subject><subject>Eosinophil Peroxidase - metabolism</subject><subject>eosinophils</subject><subject>Eosinophils - drug effects</subject><subject>Eosinophils - metabolism</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Leukotriene C4 - metabolism</subject><subject>Medical sciences</subject><subject>Mitogen-Activated Protein Kinase 1 - drug effects</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3 - drug effects</subject><subject>Mitogen-Activated Protein Kinase 3 - metabolism</subject><subject>p38 Mitogen-Activated Protein Kinases - drug effects</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphorylation - drug effects</subject><subject>phytochemical</subject><subject>Pneumology</subject><subject>Research Papers</subject><subject>Stilbenes - administration & dosage</subject><subject>Stilbenes - pharmacology</subject><subject>Time Factors</subject><subject>Vitaceae</subject><subject>Wine</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9vFCEcxYnR2LV682yIiZ52Vn4MA1yaaGOtSRON0TMBhumyYWGFma29-Sf4N_qXlHU3bfVgOJDwPjy-jwfAc4wWGFHxxqw2C4KQWFCKHoAZbnnXMCrwQzBDCPEGYyGOwJNSVghVkbPH4AgLzjuJ-QzYMetYfv_89cWVrct6zCnMoY7Q_aiKHWEaYHY9vPLRzaGPS2_8WOByWu-YVHxMm6UPsKJ-q0efYr3cw95dVt8p_Dl5Ch4NOhT37LAfg29n77-enjcXnz58PH170VjGBWmMGyxhlmAirBHGdFRopJk0fUcZJWwQvG9tJ2xr9CCZlqJFFItO2r5FouX0GJzsfTeTWbveulgjBLXJfq3ztUraq7-V6JfqMm0VYZITRqvB64NBTt8nV0a19sW6EHR0aSoKSyYZ69oKvvwHXKUpxxpOEcwJYrSVFZrvIZtTKdkNt5NgpHbVqVqd2lWnanUVf3F_-jv40FUFXh0AXawOQ_1g68stR5DkHSG7FHjPXfngrv_7qHr3-ZySum4AprOzZQ</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Tan, Y</creator><creator>Lim, L H K</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>200812</creationdate><title>trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation</title><author>Tan, Y ; Lim, L H K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5782-befc25c2128cb8bb638a0a59bd635325f87d4c68c4baf95a984031869cd408473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>asthma</topic><topic>Biological and medical sciences</topic><topic>Cell Degranulation - drug effects</topic><topic>chemotaxis</topic><topic>Chemotaxis, Leukocyte - drug effects</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Dose-Response Relationship, Drug</topic><topic>eosinophil activation</topic><topic>Eosinophil Peroxidase - drug effects</topic><topic>Eosinophil Peroxidase - metabolism</topic><topic>eosinophils</topic><topic>Eosinophils - drug effects</topic><topic>Eosinophils - metabolism</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Leukotriene C4 - metabolism</topic><topic>Medical sciences</topic><topic>Mitogen-Activated Protein Kinase 1 - drug effects</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - drug effects</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>p38 Mitogen-Activated Protein Kinases - drug effects</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphorylation - drug effects</topic><topic>phytochemical</topic><topic>Pneumology</topic><topic>Research Papers</topic><topic>Stilbenes - administration & dosage</topic><topic>Stilbenes - pharmacology</topic><topic>Time Factors</topic><topic>Vitaceae</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Y</creatorcontrib><creatorcontrib>Lim, L H K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Y</au><au>Lim, L H K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2008-12</date><risdate>2008</risdate><volume>155</volume><issue>7</issue><spage>995</spage><epage>1004</epage><pages>995-1004</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>Background and purpose:
trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not been investigated.
Experimental approach:
Human eosinophils were isolated and purified from whole blood and incubated for 16 h with trans‐resveratrol. Eosinophil chemotaxis, activation and degranulation, and apoptosis were investigated. The effect of trans‐resveratrol on the inhibition of p38 and ERK1/2 activation was examined.
Key results:
Treatment of human eosinophils with trans‐resveratrol at concentrations <100 μM for 16 h did not induce eosinophil apoptosis. Similar results were seen after 24 h and 48 h incubations. trans‐Resveratrol (<100 μM) significantly inhibited eosinophil peroxidase release after activation with IL‐5 (IC50=2.9±0.9 μM) or C5a (IC50=3.9±0.5 μM) after 5 min priming with cytochalasin B (CB). Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans‐resveratrol, at concentrations above 5 μM. All the activators induced p38 and ERK1/2 phosphorylation maximal at 2 min of activation. trans‐Resveratrol potently inhibited p38 and ERK1/2 activation after calcium ionophore and CB and C5a activation.
Conclusions and implications:
trans‐Resveratrol is effective at inhibiting human eosinophil activation and degranulation at concentrations <100 μM, while not inducing apoptosis. This potent anti‐inflammatory activity of trans‐resveratrol and possibly its metabolites on eosinophils may be worth investigating for the treatment of eosinophil‐related allergic diseases.
British Journal of Pharmacology (2008) 155, 995–1004; doi:10.1038/bjp.2008.330; published online 8 September 2008</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18776917</pmid><doi>10.1038/bjp.2008.330</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology apoptosis Apoptosis - drug effects asthma Biological and medical sciences Cell Degranulation - drug effects chemotaxis Chemotaxis, Leukocyte - drug effects Chronic obstructive pulmonary disease, asthma Dose-Response Relationship, Drug eosinophil activation Eosinophil Peroxidase - drug effects Eosinophil Peroxidase - metabolism eosinophils Eosinophils - drug effects Eosinophils - metabolism Humans Inhibitory Concentration 50 Leukotriene C4 - metabolism Medical sciences Mitogen-Activated Protein Kinase 1 - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - drug effects Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - drug effects p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Phosphorylation - drug effects phytochemical Pneumology Research Papers Stilbenes - administration & dosage Stilbenes - pharmacology Time Factors Vitaceae Wine |
| title | trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation |
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