trans‐Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation

Background and purpose: trans‐Resveratrol, a non‐flavonoid polyphenol found abundantly in red wine possesses antiproliferative and anti‐inflammatory activity in various inflammatory disease conditions. However, the effect of trans‐resveratrol on eosinophil activation in relation to allergy has not been investigated. Experimental approach: Human eosinophils were isolated and purified from whole blood and incubated for 16 h with trans‐resveratrol. Eosinophil chemotaxis, activation and degranulation, and apoptosis were investigated. The effect of trans‐resveratrol on the inhibition of p38 and ERK1/2 activation was examined. Key results: Treatment of human eosinophils with trans‐resveratrol at concentrations