Broad HIV-1 neutralization mediated by CD4-binding site antibodies

We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120. Novel...

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Veröffentlicht in:	Nature medicine 2007-09, Vol.13 (9), p.1032-1034
Hauptverfasser:	Li, Yuxing, Migueles, Stephen A, Welcher, Brent, Svehla, Krisha, Phogat, Adhuna, Louder, Mark K, Wu, Xueling, Shaw, George M, Connors, Mark, Wyatt, Richard T, Mascola, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - immunology Adsorption Antigens, CD - immunology Binding sites Binding Sites, Antibody Biomedical and Life Sciences Biomedicine Blood tests brief-communication Cancer Research CD4 Antigens - immunology CD4 lymphocytes Cohort Studies Genetic aspects Health aspects HIV HIV (Viruses) HIV Antibodies - immunology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immune recognition Immune system Immunology Infectious Diseases Medical research Metabolic Diseases Molecular Medicine Neurosciences Neutralization Neutralization Tests Physiological aspects Vaccines
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Zusammenfassung:	We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1–infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm1624