Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma

Caveolin-1 (Cav-1) plays an important role in modulating cellular signalling, but its role in metastasis is not well defined. A significant reduction in Cav-1 levels was detected in lymph node metastases as compared with primary tumour of head and neck squamous cell carcinoma (HNSCC) specimens ( P

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Veröffentlicht in:	British journal of cancer 2008-11, Vol.99 (10), p.1684-1694
Hauptverfasser:	Zhang, H, Su, L, Müller, S, Tighiouart, M, Xu, Z, Zhang, X, Shin, H J C, Hunt, J, Sun, S-Y, Shin, D M, Chen, Z(G)
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoikis Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - physiopathology Caveolin 1 - biosynthesis Cell growth Cell Line, Tumor Cell Proliferation Disease Models, Animal Down-Regulation Drug Resistance Epidemiology Female Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - physiopathology Hematology Humans Kinases Lymph Nodes - pathology Lymphatic Metastasis - physiopathology Lymphatic system Male Medical research Metastasis Mice Mice, Nude Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Metastasis Oncology Pathology Proteins Tumors Xenograft Model Antitumor Assays
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Zusammenfassung:	Caveolin-1 (Cav-1) plays an important role in modulating cellular signalling, but its role in metastasis is not well defined. A significant reduction in Cav-1 levels was detected in lymph node metastases as compared with primary tumour of head and neck squamous cell carcinoma (HNSCC) specimens ( P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6604735