Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery

This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric mi...

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Veröffentlicht in:Molecular pharmaceutics 2005-07, Vol.2 (4), p.264-272
Hauptverfasser: Ambade, Ashootosh V, Savariar, Elamprakash N, Thayumanavan, S
Format: Artikel
Sprache:eng
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Zusammenfassung:This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric micelle-based approaches precede the work in dendrimers, these are also discussed briefly. The review concludes with a perspective on possible applications of biaryl-based dendrimeric micelles that exhibit environment-dependent conformations, in drug delivery. Keywords: Micelle; drug delivery; dendrimers; controlled release; targeted delivery; polymer−drug conjugates
ISSN:1543-8384
1543-8392
DOI:10.1021/mp050020d