Low cobalamin levels in african americans with and without sickle cell disease
About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory ch...
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| Veröffentlicht in: | Journal of the National Medical Association 2006-03, Vol.98 (3), p.352-356 |
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| creator | KAMINENI, Padma CHIRLA, Suguna DINH, Kimberly HASAN, Syed NIDHIRY, Emmanuel KWAGYAN, John NAAB, Tammey LOMBARDO, Fredric CASTRO, Oswaldo DAWKINS, Fitzroy |
| description | About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory characteristics of low serum cobalamin levels in patients with SCD with those patients without this hemoglobinopathy (non-SCD). Between 1993 and 2003, 105 SCD patients and 112 non-SCD patients who had serum cobalamin measurements were identified at our institution. The mean cobalamin level in SCD patients was significantly lower (496 +/- 352 pg/ml) than that in patients without SCD (869 +/- 660 pg/ml, p |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2576129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67816622</sourcerecordid><originalsourceid>FETCH-LOGICAL-p321t-2d5befdcaac8fc361a3572a93d3ac6d46970b4ce0853d19b6641e777dd707f723</originalsourceid><addsrcrecordid>eNpdkN1LwzAUxYsobk7_BSmCvhXy0STNiyDDLxj6os_hNkldZtrMpt3wv7eb8_PpHrg_zj3n7iVjLHOa5VzS_WSMEBGZ5EU-So5iXCCECsnYYTLCnAlKZDFOHmZhnepQgofaNam3K-tjOiioWqdhmLXdipiuXTdPoTFbEfoujU6_eptq631qXLQQ7XFyUIGP9mQ3J8nzzfXT9C6bPd7eT69m2ZIS3GXEsNJWRgPootKUY6BMEJDUUNDcDPEFKnNtUcGowbLkPMdWCGGMQKIShE6Sy0_fZV_W1mjbdC14tWxdDe27CuDU303j5uolrBRhgmMiB4OLnUEb3nobO1W7uGkCjQ19VFwUmHOyuXT2D1yEvm2GcorgHDFCOBqg099xvnN8_XkAzncARA2-aqHRLv5wgheMSEI_AGvPiIA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214052260</pqid></control><display><type>article</type><title>Low cobalamin levels in african americans with and without sickle cell disease</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>PubMed Central</source><creator>KAMINENI, Padma ; CHIRLA, Suguna ; DINH, Kimberly ; HASAN, Syed ; NIDHIRY, Emmanuel ; KWAGYAN, John ; NAAB, Tammey ; LOMBARDO, Fredric ; CASTRO, Oswaldo ; DAWKINS, Fitzroy</creator><creatorcontrib>KAMINENI, Padma ; CHIRLA, Suguna ; DINH, Kimberly ; HASAN, Syed ; NIDHIRY, Emmanuel ; KWAGYAN, John ; NAAB, Tammey ; LOMBARDO, Fredric ; CASTRO, Oswaldo ; DAWKINS, Fitzroy</creatorcontrib><description>About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory characteristics of low serum cobalamin levels in patients with SCD with those patients without this hemoglobinopathy (non-SCD). Between 1993 and 2003, 105 SCD patients and 112 non-SCD patients who had serum cobalamin measurements were identified at our institution. The mean cobalamin level in SCD patients was significantly lower (496 +/- 352 pg/ml) than that in patients without SCD (869 +/- 660 pg/ml, p<0.0001). The frequency of low cobalamin levels, defined by a serum cobalamin level of <200 pg/ml, was 18.1% (19/105) and 9.8% (11/112) in SCD and non-SCD patients, respectively (chi2=3.11, nonsignificant). The mean age of the low-cobalamin SCD and non-SCD patients was 28.1 and 62.9, respectively, and their male:female ratios were 11:8 in SCD patients and 2:9 in non-SCD patients. None of the SCD patients had neurological manifestations, but nine of the 11 non-SCD low-cobalamin level patients did. The proportion of SCD patients with unexplained low cobalamin levels (13/19) was higher than that in non-SCD patients (4/11, chi2=2.92, nonsignificant) Our data suggest that cobalamin levels are lower in SCD patients than in subjects without SCD, and low-cobalamin SCD patients are younger and more likely to be males.</description><identifier>ISSN: 0027-9684</identifier><identifier>EISSN: 1943-4693</identifier><identifier>PMID: 16573298</identifier><identifier>CODEN: JNMAAE</identifier><language>eng</language><publisher>Thorofare, NJ: Slack</publisher><subject>Adult ; African Americans ; Aged ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - ethnology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Case-Control Studies ; Diseases of red blood cells ; Female ; General aspects ; Hematologic and hematopoietic diseases ; Humans ; Male ; Medical sciences ; Middle Aged ; Vitamin B 12 - blood</subject><ispartof>Journal of the National Medical Association, 2006-03, Vol.98 (3), p.352-356</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright National Medical Association Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576129/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/214052260?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17685292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16573298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMINENI, Padma</creatorcontrib><creatorcontrib>CHIRLA, Suguna</creatorcontrib><creatorcontrib>DINH, Kimberly</creatorcontrib><creatorcontrib>HASAN, Syed</creatorcontrib><creatorcontrib>NIDHIRY, Emmanuel</creatorcontrib><creatorcontrib>KWAGYAN, John</creatorcontrib><creatorcontrib>NAAB, Tammey</creatorcontrib><creatorcontrib>LOMBARDO, Fredric</creatorcontrib><creatorcontrib>CASTRO, Oswaldo</creatorcontrib><creatorcontrib>DAWKINS, Fitzroy</creatorcontrib><title>Low cobalamin levels in african americans with and without sickle cell disease</title><title>Journal of the National Medical Association</title><addtitle>J Natl Med Assoc</addtitle><description>About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory characteristics of low serum cobalamin levels in patients with SCD with those patients without this hemoglobinopathy (non-SCD). Between 1993 and 2003, 105 SCD patients and 112 non-SCD patients who had serum cobalamin measurements were identified at our institution. The mean cobalamin level in SCD patients was significantly lower (496 +/- 352 pg/ml) than that in patients without SCD (869 +/- 660 pg/ml, p<0.0001). The frequency of low cobalamin levels, defined by a serum cobalamin level of <200 pg/ml, was 18.1% (19/105) and 9.8% (11/112) in SCD and non-SCD patients, respectively (chi2=3.11, nonsignificant). The mean age of the low-cobalamin SCD and non-SCD patients was 28.1 and 62.9, respectively, and their male:female ratios were 11:8 in SCD patients and 2:9 in non-SCD patients. None of the SCD patients had neurological manifestations, but nine of the 11 non-SCD low-cobalamin level patients did. The proportion of SCD patients with unexplained low cobalamin levels (13/19) was higher than that in non-SCD patients (4/11, chi2=2.92, nonsignificant) Our data suggest that cobalamin levels are lower in SCD patients than in subjects without SCD, and low-cobalamin SCD patients are younger and more likely to be males.</description><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - ethnology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Vitamin B 12 - blood</subject><issn>0027-9684</issn><issn>1943-4693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkN1LwzAUxYsobk7_BSmCvhXy0STNiyDDLxj6os_hNkldZtrMpt3wv7eb8_PpHrg_zj3n7iVjLHOa5VzS_WSMEBGZ5EU-So5iXCCECsnYYTLCnAlKZDFOHmZhnepQgofaNam3K-tjOiioWqdhmLXdipiuXTdPoTFbEfoujU6_eptq631qXLQQ7XFyUIGP9mQ3J8nzzfXT9C6bPd7eT69m2ZIS3GXEsNJWRgPootKUY6BMEJDUUNDcDPEFKnNtUcGowbLkPMdWCGGMQKIShE6Sy0_fZV_W1mjbdC14tWxdDe27CuDU303j5uolrBRhgmMiB4OLnUEb3nobO1W7uGkCjQ19VFwUmHOyuXT2D1yEvm2GcorgHDFCOBqg099xvnN8_XkAzncARA2-aqHRLv5wgheMSEI_AGvPiIA</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>KAMINENI, Padma</creator><creator>CHIRLA, Suguna</creator><creator>DINH, Kimberly</creator><creator>HASAN, Syed</creator><creator>NIDHIRY, Emmanuel</creator><creator>KWAGYAN, John</creator><creator>NAAB, Tammey</creator><creator>LOMBARDO, Fredric</creator><creator>CASTRO, Oswaldo</creator><creator>DAWKINS, Fitzroy</creator><general>Slack</general><general>Elsevier Limited</general><general>National Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060301</creationdate><title>Low cobalamin levels in african americans with and without sickle cell disease</title><author>KAMINENI, Padma ; CHIRLA, Suguna ; DINH, Kimberly ; HASAN, Syed ; NIDHIRY, Emmanuel ; KWAGYAN, John ; NAAB, Tammey ; LOMBARDO, Fredric ; CASTRO, Oswaldo ; DAWKINS, Fitzroy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-2d5befdcaac8fc361a3572a93d3ac6d46970b4ce0853d19b6641e777dd707f723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - ethnology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAMINENI, Padma</creatorcontrib><creatorcontrib>CHIRLA, Suguna</creatorcontrib><creatorcontrib>DINH, Kimberly</creatorcontrib><creatorcontrib>HASAN, Syed</creatorcontrib><creatorcontrib>NIDHIRY, Emmanuel</creatorcontrib><creatorcontrib>KWAGYAN, John</creatorcontrib><creatorcontrib>NAAB, Tammey</creatorcontrib><creatorcontrib>LOMBARDO, Fredric</creatorcontrib><creatorcontrib>CASTRO, Oswaldo</creatorcontrib><creatorcontrib>DAWKINS, Fitzroy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the National Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAMINENI, Padma</au><au>CHIRLA, Suguna</au><au>DINH, Kimberly</au><au>HASAN, Syed</au><au>NIDHIRY, Emmanuel</au><au>KWAGYAN, John</au><au>NAAB, Tammey</au><au>LOMBARDO, Fredric</au><au>CASTRO, Oswaldo</au><au>DAWKINS, Fitzroy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low cobalamin levels in african americans with and without sickle cell disease</atitle><jtitle>Journal of the National Medical Association</jtitle><addtitle>J Natl Med Assoc</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>98</volume><issue>3</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0027-9684</issn><eissn>1943-4693</eissn><coden>JNMAAE</coden><abstract>About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory characteristics of low serum cobalamin levels in patients with SCD with those patients without this hemoglobinopathy (non-SCD). Between 1993 and 2003, 105 SCD patients and 112 non-SCD patients who had serum cobalamin measurements were identified at our institution. The mean cobalamin level in SCD patients was significantly lower (496 +/- 352 pg/ml) than that in patients without SCD (869 +/- 660 pg/ml, p<0.0001). The frequency of low cobalamin levels, defined by a serum cobalamin level of <200 pg/ml, was 18.1% (19/105) and 9.8% (11/112) in SCD and non-SCD patients, respectively (chi2=3.11, nonsignificant). The mean age of the low-cobalamin SCD and non-SCD patients was 28.1 and 62.9, respectively, and their male:female ratios were 11:8 in SCD patients and 2:9 in non-SCD patients. None of the SCD patients had neurological manifestations, but nine of the 11 non-SCD low-cobalamin level patients did. The proportion of SCD patients with unexplained low cobalamin levels (13/19) was higher than that in non-SCD patients (4/11, chi2=2.92, nonsignificant) Our data suggest that cobalamin levels are lower in SCD patients than in subjects without SCD, and low-cobalamin SCD patients are younger and more likely to be males.</abstract><cop>Thorofare, NJ</cop><pub>Slack</pub><pmid>16573298</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult African Americans Aged Anemia, Sickle Cell - blood Anemia, Sickle Cell - ethnology Anemias. Hemoglobinopathies Biological and medical sciences Case-Control Studies Diseases of red blood cells Female General aspects Hematologic and hematopoietic diseases Humans Male Medical sciences Middle Aged Vitamin B 12 - blood |
| title | Low cobalamin levels in african americans with and without sickle cell disease |
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