Low cobalamin levels in african americans with and without sickle cell disease

Low cobalamin levels in african americans with and without sickle cell disease

About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory ch...

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Veröffentlicht in:Journal of the National Medical Association 2006-03, Vol.98 (3), p.352-356
Hauptverfasser: KAMINENI, Padma, CHIRLA, Suguna, DINH, Kimberly, HASAN, Syed, NIDHIRY, Emmanuel, KWAGYAN, John, NAAB, Tammey, LOMBARDO, Fredric, CASTRO, Oswaldo, DAWKINS, Fitzroy
Format: Artikel
Sprache:eng
Schlagworte:
Adult
African Americans
Aged
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - ethnology
Anemias. Hemoglobinopathies
Biological and medical sciences
Case-Control Studies
Diseases of red blood cells
Female
General aspects
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Middle Aged
Vitamin B 12 - blood
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Zusammenfassung:About 7% of the adult population has subclinical cobalamin (B12) deficiency. Subjects with sickle cell disease (SCD) may be at higher risk of cobalamin deficiency because of increased demand, inadequate supply, coexisting folate deficiency or malabsorption. We compared the clinical and laboratory characteristics of low serum cobalamin levels in patients with SCD with those patients without this hemoglobinopathy (non-SCD). Between 1993 and 2003, 105 SCD patients and 112 non-SCD patients who had serum cobalamin measurements were identified at our institution. The mean cobalamin level in SCD patients was significantly lower (496 +/- 352 pg/ml) than that in patients without SCD (869 +/- 660 pg/ml, p
ISSN:0027-9684
1943-4693