Molecular targeted therapies for breast cancer treatment

Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduc...

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Veröffentlicht in:	Breast cancer research : BCR 2008-01, Vol.10 (4), p.211-211, Article 211
Hauptverfasser:	Schlotter, Claus M, Vogt, Ulf, Allgayer, Heike, Brandt, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Cycle Cell Line, Tumor Female Humans Models, Biological Neovascularization, Pathologic NF-kappa B - metabolism Proteasome Endopeptidase Complex - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Review Signal Transduction Ubiquitin - metabolism
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Beschreibung
Zusammenfassung:	Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.
ISSN:	1465-542X 1465-5411 1465-542X
DOI:	10.1186/bcr2112