Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells

A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellula...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-10, Vol.51 (20), p.6256-6258
Hauptverfasser:	Cvek, Boris, Milacic, Vesna, Taraba, Jan, Dou, Q. Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Copper Ditiocarb - analogs & derivatives Ditiocarb - chemistry Ditiocarb - pharmacology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Humans Medical sciences Molecular Structure Nickel Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Zinc
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Beschreibung
Zusammenfassung:	A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm8007807