Western Equine Encephalitis submergence: Lack of evidence for a decline in virus virulence

Abstract The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1–2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanat...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-10, Vol.380 (2), p.170-172
Hauptverfasser:	Forrester, Naomi L, Kenney, Joan L, Deardorff, Eleanor, Wang, Eryu, Weaver, Scott C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight disease incidence Encephalitis Virus, Western Equine - pathogenicity Encephalomyelitis, Western Equine - epidemiology Encephalomyelitis, Western Equine - virology horse diseases horses Humans Incidence Infectious Disease Mice pathogenicity Survival Analysis Virulence Western Equine Encephalitis virus Western equine encephalomyelitis
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Zusammenfassung:	Abstract The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1–2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should be investigated to explain the decline in WEE.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/j.virol.2008.08.012