Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation
BACKGROUND. The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year. METHODS. CKD was defined as...
Gespeichert in:
| Veröffentlicht in: | Cancer 2008-10, Vol.113 (7), p.1580-1587 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1587 |
|---|---|
| container_issue | 7 |
| container_start_page | 1580 |
| container_title | Cancer |
| container_volume | 113 |
| creator | Choi, Michael Sun, Can‐Lan Kurian, Seira Carter, Andrea Francisco, Liton Forman, Stephen J Bhatia, Smita |
| description | BACKGROUND.
The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.
METHODS.
CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of |
| doi_str_mv | 10.1002/cncr.23773 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2571082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69591128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5143-6bb5fbabd7d094a1aa0ab3268e55f008111806489c45cd2402c4cc874df548393</originalsourceid><addsrcrecordid>eNp9kc-KFDEQxoMo7rh68QEkFz0IvSbppDt9EWTwz8KiIAreQjqp3ommkzbpGembj-Az-iRmnGbVi6dQ5FffV1UfQg8puaCEsGcmmHTB6ratb6ENJV1bEcrZbbQhhMhK8PrTGbqX8-dStkzUd9EZlS3hnWw2aLkMxlkIBrAOFk8JrDNzTBnHAVvwegGLzS7F4Az-4myABVuXQWfALmAfw_XP7z9mSCPO-3Rwh7V1B6Oe4xQdzKXRgPd4Tjrkyesw69nFcB_dGbTP8GB9z9HHVy8_bN9UV-9eX25fXFVGUF5XTd-Lode9bS3puKZaE93XrJEgxFD2o5RK0nDZGS6MZZwww42RLbeD4LLu6nP0_KQ77fsRrIFQBvFqSm7UaVFRO_XvT3A7dR0PiomWEsmKwJNVIMWve8izGl0-bqQDxH1WTSc6Spks4NMTaFLMOcFwY0KJOialjkmp30kV-NHfY_1B12gK8HgFdDbaD-V6xuUbjpGOcElo4eiJ--Y8LP-xVNu32_cn819HPrAs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69591128</pqid></control><display><type>article</type><title>Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Choi, Michael ; Sun, Can‐Lan ; Kurian, Seira ; Carter, Andrea ; Francisco, Liton ; Forman, Stephen J ; Bhatia, Smita</creator><creatorcontrib>Choi, Michael ; Sun, Can‐Lan ; Kurian, Seira ; Carter, Andrea ; Francisco, Liton ; Forman, Stephen J ; Bhatia, Smita</creatorcontrib><description>BACKGROUND.
The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.
METHODS.
CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of <60 mL per minute per 1.73 m2 for ≥3 months. The median age at HCT was 35 years (range, 18.1‐68.6 years), and the median length of follow‐up was 7.1 years after HCT (range, 1‐24.3 years).
RESULTS.
Sixty patients with CKD were identified, resulting in a cumulative incidence of 4.4% at 5 years (autologous HCT, 3.8%; matched‐sibling HCT, 4.5%; unrelated donor HCT, 10%; P = .09 compared with autologous HCT). Older age at HCT (relative risk [RR] per 5‐year increment, 1.33; 95% confidence interval [CI], 1.2‐1.5), exposure to cyclosporine without tacrolimus (RR, 1.90; 95% CI, 1.1‐3.4) or with tacrolimus (RR, 4.59; 95% CI, 1.8‐11.5), and a primary diagnosis of multiple myeloma (RR, 2.51; 95% CI, 1.1‐5.6) were associated with an increased risk of delayed CKD.
CONCLUSIONS.
In this study, the authors identified a subpopulation of patients who underwent HCT and remained at increased risk for CKD. The current findings set the stage for appropriate long‐term follow‐up of vulnerable patients. Cancer 2008. © 2008 American Cancer Society.
In this study, the authors identified a subpopulation of patients who underwent hematopoietic cell transplantation and were at increased risk for chronic kidney disease. These findings set the stage for appropriate long‐term follow‐up of vulnerable patients.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.23773</identifier><identifier>PMID: 18704986</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Anemia, Aplastic - therapy ; Biological and medical sciences ; calcineurin inhibitors ; Chronic Disease ; Cohort Studies ; cyclosporine A ; Female ; graft‐versus‐host disease ; Hematologic Neoplasms - therapy ; hematopoietic cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Incidence ; Kidney Diseases - epidemiology ; Kidney Diseases - etiology ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; nephrotoxicity ; primary multiple myeloma ; Retrospective Studies ; Risk ; Survivors ; tacrolimus ; Transplantation, Autologous ; Transplantation, Homologous ; Tumors ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Cancer, 2008-10, Vol.113 (7), p.1580-1587</ispartof><rights>Copyright © 2008 American Cancer Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5143-6bb5fbabd7d094a1aa0ab3268e55f008111806489c45cd2402c4cc874df548393</citedby><cites>FETCH-LOGICAL-c5143-6bb5fbabd7d094a1aa0ab3268e55f008111806489c45cd2402c4cc874df548393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.23773$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.23773$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20904801$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18704986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Michael</creatorcontrib><creatorcontrib>Sun, Can‐Lan</creatorcontrib><creatorcontrib>Kurian, Seira</creatorcontrib><creatorcontrib>Carter, Andrea</creatorcontrib><creatorcontrib>Francisco, Liton</creatorcontrib><creatorcontrib>Forman, Stephen J</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><title>Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND.
The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.
METHODS.
CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of <60 mL per minute per 1.73 m2 for ≥3 months. The median age at HCT was 35 years (range, 18.1‐68.6 years), and the median length of follow‐up was 7.1 years after HCT (range, 1‐24.3 years).
RESULTS.
Sixty patients with CKD were identified, resulting in a cumulative incidence of 4.4% at 5 years (autologous HCT, 3.8%; matched‐sibling HCT, 4.5%; unrelated donor HCT, 10%; P = .09 compared with autologous HCT). Older age at HCT (relative risk [RR] per 5‐year increment, 1.33; 95% confidence interval [CI], 1.2‐1.5), exposure to cyclosporine without tacrolimus (RR, 1.90; 95% CI, 1.1‐3.4) or with tacrolimus (RR, 4.59; 95% CI, 1.8‐11.5), and a primary diagnosis of multiple myeloma (RR, 2.51; 95% CI, 1.1‐5.6) were associated with an increased risk of delayed CKD.
CONCLUSIONS.
In this study, the authors identified a subpopulation of patients who underwent HCT and remained at increased risk for CKD. The current findings set the stage for appropriate long‐term follow‐up of vulnerable patients. Cancer 2008. © 2008 American Cancer Society.
In this study, the authors identified a subpopulation of patients who underwent hematopoietic cell transplantation and were at increased risk for chronic kidney disease. These findings set the stage for appropriate long‐term follow‐up of vulnerable patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anemia, Aplastic - therapy</subject><subject>Biological and medical sciences</subject><subject>calcineurin inhibitors</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>cyclosporine A</subject><subject>Female</subject><subject>graft‐versus‐host disease</subject><subject>Hematologic Neoplasms - therapy</subject><subject>hematopoietic cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>nephrotoxicity</subject><subject>primary multiple myeloma</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Survivors</subject><subject>tacrolimus</subject><subject>Transplantation, Autologous</subject><subject>Transplantation, Homologous</subject><subject>Tumors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxoMo7rh68QEkFz0IvSbppDt9EWTwz8KiIAreQjqp3ommkzbpGembj-Az-iRmnGbVi6dQ5FffV1UfQg8puaCEsGcmmHTB6ratb6ENJV1bEcrZbbQhhMhK8PrTGbqX8-dStkzUd9EZlS3hnWw2aLkMxlkIBrAOFk8JrDNzTBnHAVvwegGLzS7F4Az-4myABVuXQWfALmAfw_XP7z9mSCPO-3Rwh7V1B6Oe4xQdzKXRgPd4Tjrkyesw69nFcB_dGbTP8GB9z9HHVy8_bN9UV-9eX25fXFVGUF5XTd-Lode9bS3puKZaE93XrJEgxFD2o5RK0nDZGS6MZZwww42RLbeD4LLu6nP0_KQ77fsRrIFQBvFqSm7UaVFRO_XvT3A7dR0PiomWEsmKwJNVIMWve8izGl0-bqQDxH1WTSc6Spks4NMTaFLMOcFwY0KJOialjkmp30kV-NHfY_1B12gK8HgFdDbaD-V6xuUbjpGOcElo4eiJ--Y8LP-xVNu32_cn819HPrAs</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Choi, Michael</creator><creator>Sun, Can‐Lan</creator><creator>Kurian, Seira</creator><creator>Carter, Andrea</creator><creator>Francisco, Liton</creator><creator>Forman, Stephen J</creator><creator>Bhatia, Smita</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081001</creationdate><title>Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation</title><author>Choi, Michael ; Sun, Can‐Lan ; Kurian, Seira ; Carter, Andrea ; Francisco, Liton ; Forman, Stephen J ; Bhatia, Smita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5143-6bb5fbabd7d094a1aa0ab3268e55f008111806489c45cd2402c4cc874df548393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anemia, Aplastic - therapy</topic><topic>Biological and medical sciences</topic><topic>calcineurin inhibitors</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>cyclosporine A</topic><topic>Female</topic><topic>graft‐versus‐host disease</topic><topic>Hematologic Neoplasms - therapy</topic><topic>hematopoietic cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>nephrotoxicity</topic><topic>primary multiple myeloma</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Survivors</topic><topic>tacrolimus</topic><topic>Transplantation, Autologous</topic><topic>Transplantation, Homologous</topic><topic>Tumors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Michael</creatorcontrib><creatorcontrib>Sun, Can‐Lan</creatorcontrib><creatorcontrib>Kurian, Seira</creatorcontrib><creatorcontrib>Carter, Andrea</creatorcontrib><creatorcontrib>Francisco, Liton</creatorcontrib><creatorcontrib>Forman, Stephen J</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Michael</au><au>Sun, Can‐Lan</au><au>Kurian, Seira</au><au>Carter, Andrea</au><au>Francisco, Liton</au><au>Forman, Stephen J</au><au>Bhatia, Smita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>113</volume><issue>7</issue><spage>1580</spage><epage>1587</epage><pages>1580-1587</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND.
The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.
METHODS.
CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of <60 mL per minute per 1.73 m2 for ≥3 months. The median age at HCT was 35 years (range, 18.1‐68.6 years), and the median length of follow‐up was 7.1 years after HCT (range, 1‐24.3 years).
RESULTS.
Sixty patients with CKD were identified, resulting in a cumulative incidence of 4.4% at 5 years (autologous HCT, 3.8%; matched‐sibling HCT, 4.5%; unrelated donor HCT, 10%; P = .09 compared with autologous HCT). Older age at HCT (relative risk [RR] per 5‐year increment, 1.33; 95% confidence interval [CI], 1.2‐1.5), exposure to cyclosporine without tacrolimus (RR, 1.90; 95% CI, 1.1‐3.4) or with tacrolimus (RR, 4.59; 95% CI, 1.8‐11.5), and a primary diagnosis of multiple myeloma (RR, 2.51; 95% CI, 1.1‐5.6) were associated with an increased risk of delayed CKD.
CONCLUSIONS.
In this study, the authors identified a subpopulation of patients who underwent HCT and remained at increased risk for CKD. The current findings set the stage for appropriate long‐term follow‐up of vulnerable patients. Cancer 2008. © 2008 American Cancer Society.
In this study, the authors identified a subpopulation of patients who underwent hematopoietic cell transplantation and were at increased risk for chronic kidney disease. These findings set the stage for appropriate long‐term follow‐up of vulnerable patients.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18704986</pmid><doi>10.1002/cncr.23773</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 2008-10, Vol.113 (7), p.1580-1587 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2571082 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anemia, Aplastic - therapy Biological and medical sciences calcineurin inhibitors Chronic Disease Cohort Studies cyclosporine A Female graft‐versus‐host disease Hematologic Neoplasms - therapy hematopoietic cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Incidence Kidney Diseases - epidemiology Kidney Diseases - etiology Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases nephrotoxicity primary multiple myeloma Retrospective Studies Risk Survivors tacrolimus Transplantation, Autologous Transplantation, Homologous Tumors Urinary system involvement in other diseases. Miscellaneous |
| title | Incidence and predictors of delayed chronic kidney disease in long‐term survivors of hematopoietic cell transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T04%3A33%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20and%20predictors%20of%20delayed%20chronic%20kidney%20disease%20in%20long%E2%80%90term%20survivors%20of%20hematopoietic%20cell%20transplantation&rft.jtitle=Cancer&rft.au=Choi,%20Michael&rft.date=2008-10-01&rft.volume=113&rft.issue=7&rft.spage=1580&rft.epage=1587&rft.pages=1580-1587&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/cncr.23773&rft_dat=%3Cproquest_pubme%3E69591128%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69591128&rft_id=info:pmid/18704986&rfr_iscdi=true |