Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2008-09, Vol.205 (10), p.2409-2417
Hauptverfasser:	El-Osta, Assam, Brasacchio, Daniella, Yao, Dachun, Pocai, Alessandro, Jones, Peter L, Roeder, Robert G, Cooper, Mark E, Brownlee, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Cattle Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Diabetes Complications Diabetes Mellitus - metabolism Endothelial Cells - cytology Endothelial Cells - physiology Epigenesis, Genetic Gene Expression Regulation Glucose - metabolism Glycated Hemoglobin A - genetics Glycated Hemoglobin A - metabolism Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Hyperglycemia - metabolism Ion Channels - genetics Ion Channels - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Promoter Regions, Genetic Protein Methyltransferases Reactive Oxygen Species - metabolism Risk Factors Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Uncoupling Protein 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism
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Beschreibung
Zusammenfassung:	The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.20081188