Mechanics of membrane fusion

Diverse membrane fusion reactions in biology involve close contact between two lipid bilayers, followed by the local distortion of the individual bilayers and reformation into a single, merged membrane. We consider the structures and energies of the fusion intermediates identified in experimental an...

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Veröffentlicht in:Nature structural & molecular biology 2008-07, Vol.15 (7), p.675-683
Hauptverfasser: Chernomordik, Leonid V, Kozlov, Michael M
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Sprache:eng
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Zusammenfassung:Diverse membrane fusion reactions in biology involve close contact between two lipid bilayers, followed by the local distortion of the individual bilayers and reformation into a single, merged membrane. We consider the structures and energies of the fusion intermediates identified in experimental and theoretical work on protein-free lipid bilayers. On the basis of this analysis, we then discuss the conserved fusion-through-hemifusion pathway of merger between biological membranes and propose that the entire progression, from the close juxtaposition of membrane bilayers to the expansion of a fusion pore, is controlled by protein-generated membrane stresses.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb.1455