Transmission of tuberculosis in British centre for patients infected with HIV

Case No Age (years) CD4 count (cellsx106/l) Date of admission(s) Location Reason for admission Tuberculosis diagnosed Outcome 1 23 100 Jun to Aug 1992 Wards A and B, hospital 1 Pulmonary tuberculosis M tuberculosis isolated from bronchoalveolar lavage fluid and sputum, Jun 1992 Recovered with standard treatment for tuberculosis 2 27 30 Jun to Jul 1992 Ward B, hospital 1 Retinal branch vein occlusion - - - - - Aug to Oct 1992 Ward B, hospital 1 Disseminated tuberculosis M tuberculosis isolated from bronchoalveolar lavage fluid and liver biopsy specimen, Sep 1992 Responded to treatment for tuberculosis Died Apr 1993 from other disease related to HIV infection 3 42 30 Jun 1992 Ward B, hospital 1 Cytomegalovirus retinitis - - - Jul 1992 Ward B, hospital 1 Hickman line infection - - - - - Aug 1992 Wards B and C, Sepsis syndrome M tuberculosis isolated from blood and urine, Aug 1992; acid fast bacilli seen in mediastinal lymph node at postmortem examination Died Aug 1992 4 41 Feb 1993 Hospital 2 Pulmonary tuberculosis M tuberculosis isolated from bronchoalveolar lavage fluid, sputum, and urine, Feb 1993 Recovered with treatment for tuberculosis *All patients were men except case 2. (dagger)On basis of pattern of restriction fragment length polymorphism and antimicrobial sensitivity.