Copper-Catalyzed Arylation and Alkenylation of Polyfluoroarene C−H Bonds

Copper-Catalyzed Arylation and Alkenylation of Polyfluoroarene C−H Bonds

An efficient, copper-catalyzed method for the arylation, alkenylation, and benzylation of polyfluoroarenes has been developed. Arenes containing two or more fluorine substituents on the aromatic ring can be efficiently functionalized. The best results are obtained by using a combination of copper io...

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Veröffentlicht in:Journal of the American Chemical Society 2008-01, Vol.130 (4), p.1128-1129
Hauptverfasser: Do, Hien-Quang, Daugulis, Olafs
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Biochemistry - methods
Bromides - chemistry
Carbon - chemistry
Chemistry - methods
Copper - chemistry
Dimethylformamide - chemistry
Fluorenes - chemistry
Fluorine - chemistry
Hydrogen - chemistry
Iodides - chemistry
Ligands
Models, Chemical
Phenanthrolines - chemistry
Solvents - chemistry
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Beschreibung
Zusammenfassung:An efficient, copper-catalyzed method for the arylation, alkenylation, and benzylation of polyfluoroarenes has been developed. Arenes containing two or more fluorine substituents on the aromatic ring can be efficiently functionalized. The best results are obtained by using a combination of copper iodide catalyst, phenanthroline ligand, aryl bromide or aryl iodide coupling partner, and DMF or DMF/xylene mixed solvent.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja077862l