Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum

[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry...

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Veröffentlicht in:	Organic letters 2005-07, Vol.7 (14), p.3017-3020
Hauptverfasser:	Harding, Wayne W, Tidgewell, Kevin, Schmidt, Matthew, Shah, Kushal, Dersch, Christina M, Snyder, John, Parrish, Damon, Deschamps, Jeffrey R, Rothman, Richard B, Prisinzano, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Diterpenes Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology Molecular Structure Narcotic Antagonists Nuclear Magnetic Resonance, Biomolecular Plant Leaves - chemistry Plants, Medicinal - chemistry Salvia - chemistry
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Zusammenfassung:	[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0510522