Denitration of L-type calcium channel
Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa v1.2b. We report here that Ca v1.2 is also subject to “denitration”. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced n...
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| Veröffentlicht in: | FEBS letters 2008-09, Vol.582 (20), p.3033-3036 |
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| creator | Kang, Minho Akbarali, Hamid I. |
| description | Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa
v1.2b. We report here that Ca
v1.2 is also subject to “denitration”. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca
v1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation. |
| doi_str_mv | 10.1016/j.febslet.2008.07.042 |
| format | Article |
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v1.2b. We report here that Ca
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v1.2b. We report here that Ca
v1.2 is also subject to “denitration”. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca
v1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation.</description><subject>Animals</subject><subject>Calcium Channels, L-Type - genetics</subject><subject>Calcium Channels, L-Type - metabolism</subject><subject>Cell Line</subject><subject>Humans</subject><subject>Ion channel</subject><subject>Mice</subject><subject>Muscle, Smooth - metabolism</subject><subject>Nitrates - metabolism</subject><subject>Nitration</subject><subject>Nitric oxide</subject><subject>Phosphorylation</subject><subject>Smooth muscle</subject><subject>Src kinase</subject><subject>Tyrosine</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - biosynthesis</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtP4zAURi3ECMrjJ4C6YXbJXL-dDYjhOVIlFsDacpwbcJUmJU476r8fV614rJiVZfm7x5_OJeSEQk6Bql_TvMYyNjjkDMDkoHMQbIeMqNE840KZXTICoCKTuuD75CDGKaS7ocUe2adGaWlAjcjZNbZh6N0Qunbc1eNJNqzmOPau8WExG_tX17bYHJEftWsiHm_PQ_J8e_N0dZ9NHu7-XF1OMq-YphmtpSygqjgyp71GxUXpkNXCOV-gRq49GCooKE2pK42ohWauqmVZeiUl44fkfMOdL8oZVh7bVK2x8z7MXL-ynQv260sbXu1Lt7RMci6ZSYCfW0DfvS0wDnYWosemcS12i2gZFNSYQqSg3AR938XYY_3-CQW7FmyndivYrgVb0DYJTnOnnxt-TG2NpsD9JvA3NLj6P6q9vfnNHtfbWi8LDIASnCbUxQaFSfkyYG-jD9h6rEKPfrBVF75p-w-quaSM</recordid><startdate>20080903</startdate><enddate>20080903</enddate><creator>Kang, Minho</creator><creator>Akbarali, Hamid I.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>20080903</creationdate><title>Denitration of L-type calcium channel</title><author>Kang, Minho ; Akbarali, Hamid I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6271-1f5590dd3e2a7c7e634bae2f4aac9e7e37c0814106711ab84f472adf5bbc65523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Calcium Channels, L-Type - genetics</topic><topic>Calcium Channels, L-Type - metabolism</topic><topic>Cell Line</topic><topic>Humans</topic><topic>Ion channel</topic><topic>Mice</topic><topic>Muscle, Smooth - metabolism</topic><topic>Nitrates - metabolism</topic><topic>Nitration</topic><topic>Nitric oxide</topic><topic>Phosphorylation</topic><topic>Smooth muscle</topic><topic>Src kinase</topic><topic>Tyrosine</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Minho</creatorcontrib><creatorcontrib>Akbarali, Hamid I.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Minho</au><au>Akbarali, Hamid I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Denitration of L-type calcium channel</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2008-09-03</date><risdate>2008</risdate><volume>582</volume><issue>20</issue><spage>3033</spage><epage>3036</epage><pages>3033-3036</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa
v1.2b. We report here that Ca
v1.2 is also subject to “denitration”. Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca
v1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>18675806</pmid><doi>10.1016/j.febslet.2008.07.042</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Cell Line Humans Ion channel Mice Muscle, Smooth - metabolism Nitrates - metabolism Nitration Nitric oxide Phosphorylation Smooth muscle Src kinase Tyrosine Tyrosine - analogs & derivatives Tyrosine - biosynthesis |
| title | Denitration of L-type calcium channel |
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