Enantioselective Total Synthesis of (+)-Gliocladin C

Enantioselective Total Synthesis of (+)-Gliocladin C

The first total synthesis of gliocladin C, a fungal-derived marine alkaloid containing a rare trioxopiperazine fragment, is reported. This asymmetric synthesis establishes the absolute configuration of this structurally novel natural product.

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Veröffentlicht in:Organic letters 2007-01, Vol.9 (2), p.339-341
Hauptverfasser: Overman, Larry E, Shin, Youseung
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemical synthesis
Alkaloids - chemistry
Biological Products - chemical synthesis
Biological Products - chemistry
Molecular Conformation
Piperazines - chemical synthesis
Piperazines - chemistry
Pyrrolidinones - chemical synthesis
Pyrrolidinones - chemistry
Stereoisomerism
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Zusammenfassung:The first total synthesis of gliocladin C, a fungal-derived marine alkaloid containing a rare trioxopiperazine fragment, is reported. This asymmetric synthesis establishes the absolute configuration of this structurally novel natural product.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol062801y