Light cigarette smoke-induced emphysema and NFκB activation in mouse lung

Summary Light cigarette (LC) exposure is supposed to be less hazardous with a decreased incidence of cancer and tobacco‐associated diseases. C57BL/6 mouse groups were subjected to smoke from 3, 6 or 12 LC for 60 days and compared with mice exposed to ambient air (EAA) in order to study lung injury by morphometrical and biochemical methods. Bronchoalveolar lavage (BAL) analysis and histology and stereology were performed. Tissue from the right lung was used for measuring thiobarbituric acid reactive substances (TBARS) and Western blot analysis. One way anova was performed followed by the Student–Newman Keuls post‐test (P