'Brugada ECG' elicited by imipramine overdose

'Brugada ECG' elicited by imipramine overdose

The ECG hallmark of the Brugada syndrome is ST-segment elevation in the right precordial leads. However, a 'Brugada ECG' may also occasionally be caused by other conditions. We report a case of a Brugada ECG due to an overdose of imipramine, a tricyclic antidepressant. The patient, a 66-ye...

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Veröffentlicht in:Netherlands heart journal 2004-09, Vol.12 (9), p.404-406
Hauptverfasser: van den Berg, M P, Tulleken, J E, Wilde, A A M
Format: Artikel
Sprache:eng
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Case Report
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Zusammenfassung:The ECG hallmark of the Brugada syndrome is ST-segment elevation in the right precordial leads. However, a 'Brugada ECG' may also occasionally be caused by other conditions. We report a case of a Brugada ECG due to an overdose of imipramine, a tricyclic antidepressant. The patient, a 66-year-old woman, was admitted to the emergency unit in a comatose state, due to autointoxication with imipramine. In addition to other signs of massive sodium-channel blockade, the ECG showed typical ST-segment elevation in the right precordial and the inferior leads. The abnormalities resolved quickly after administration of sodium bicarbonate.
ISSN:1568-5888