Laboratory aspects of intermittent drug therapy

The drug-parasite relationships for isoniazid and rifampicin have been investigated, using cultures of M. tuberculosis and infected guinea-pigs. It is remarkable that there appear to be two entirely different mechanisms involved in intermittent chemotherapy with isoniazid and rifampicin. With isonia...

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Veröffentlicht in:	Postgraduate medical journal 1971-11, Vol.47 (553), p.737-741
Hauptverfasser:	Mitchison, D. A., Dickinson, Jean M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ethionamide - therapeutic use Growth - drug effects Guinea Pigs Humans Isoniazid - administration & dosage Isoniazid - blood Rifampin - administration & dosage Streptomycin - therapeutic use Thioacetazone - therapeutic use Time Factors Tuberculosis - drug therapy Tuberculosis in the 1970s
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Zusammenfassung:	The drug-parasite relationships for isoniazid and rifampicin have been investigated, using cultures of M. tuberculosis and infected guinea-pigs. It is remarkable that there appear to be two entirely different mechanisms involved in intermittent chemotherapy with isoniazid and rifampicin. With isoniazid, any escape from the influence of the drug leads to diminished efficacy. On the other hand, with rifampicin, it is just this escape that promotes higher efficacy.
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.47.553.737