Aging by epigenetics—A consequence of chromatin damage?
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-de...
Gespeichert in:
| Veröffentlicht in: | Experimental cell research 2008-06, Vol.314 (9), p.1909-1917 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1917 |
|---|---|
| container_issue | 9 |
| container_start_page | 1909 |
| container_title | Experimental cell research |
| container_volume | 314 |
| creator | Sedivy, John M. Banumathy, Gowrishankar Adams, Peter D. |
| description | Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases. |
| doi_str_mv | 10.1016/j.yexcr.2008.02.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2464300</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014482708001109</els_id><sourcerecordid>69207575</sourcerecordid><originalsourceid>FETCH-LOGICAL-c543t-e15757deb4f6db0a21468c4b8fb20731696a21ea426d22bfa2c3d3a552c001da3</originalsourceid><addsrcrecordid>eNqFkcuqFDEQhoMonvHoEwjSKLjrMamkM90LleHgDQ640XVIp6t7MkwnY9JzcHY-hE_ok1jtDN4WCgWB1FeXv37GHgq-FFzoZ9vlET-7tATO6yUHCnmLLQRveAkK4DZbcC5UqWpYXbB7OW85gbXQd9mFqBVIzfWCNevBh6FojwXu_YABJ-_yty9f14WLIeOnAwaHRewLt0lxtJMPRWdHO-DL--xOb3cZH5zfS_bx9asPV2_L6_dv3l2tr0tXKTmVKKpVteqwVb3uWm5BKF071dZ9C3wlhW40_aFVoDuAtrfgZCdtVYGj9TsrL9mLU9_9oR2xcximZHdmn_xo09FE682fmeA3Zog3BpRWknNq8OTUIObJm-z8hG5D6gK6yYAQUIu6IurpeUyKpDpPZvTZ4W5nA8ZDNrqhdUnKf0HgoEm5IPDxX-A2HlKgWxnR0BGqRkmC5AlyKeacsP8pTHAz22y25ofNZrbZcKCYqx79fpNfNWdfCXh-ApCcufGYZt2zlZ1Ps-wu-n8O-A6Sgrmz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>194685943</pqid></control><display><type>article</type><title>Aging by epigenetics—A consequence of chromatin damage?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sedivy, John M. ; Banumathy, Gowrishankar ; Adams, Peter D.</creator><creatorcontrib>Sedivy, John M. ; Banumathy, Gowrishankar ; Adams, Peter D.</creatorcontrib><description>Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/j.yexcr.2008.02.023</identifier><identifier>PMID: 18423606</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; AGING ; Aging - genetics ; Animals ; Cancer ; Cell senescence ; Cellular biology ; CHROMATIN ; Chromatin - genetics ; Chromatin - pathology ; Chromatin Assembly and Disassembly ; DNA DAMAGES ; Epigenesis, Genetic ; Epigenetics ; Humans ; Life expectancy ; Longevity ; NEOPLASMS ; Progeria - pathology ; STOCHASTIC PROCESSES ; Yeasts - physiology</subject><ispartof>Experimental cell research, 2008-06, Vol.314 (9), p.1909-1917</ispartof><rights>2008 Elsevier Inc.</rights><rights>Copyright © 2008 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-e15757deb4f6db0a21468c4b8fb20731696a21ea426d22bfa2c3d3a552c001da3</citedby><cites>FETCH-LOGICAL-c543t-e15757deb4f6db0a21468c4b8fb20731696a21ea426d22bfa2c3d3a552c001da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014482708001109$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18423606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/21128185$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedivy, John M.</creatorcontrib><creatorcontrib>Banumathy, Gowrishankar</creatorcontrib><creatorcontrib>Adams, Peter D.</creatorcontrib><title>Aging by epigenetics—A consequence of chromatin damage?</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>AGING</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Cancer</subject><subject>Cell senescence</subject><subject>Cellular biology</subject><subject>CHROMATIN</subject><subject>Chromatin - genetics</subject><subject>Chromatin - pathology</subject><subject>Chromatin Assembly and Disassembly</subject><subject>DNA DAMAGES</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Longevity</subject><subject>NEOPLASMS</subject><subject>Progeria - pathology</subject><subject>STOCHASTIC PROCESSES</subject><subject>Yeasts - physiology</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuqFDEQhoMonvHoEwjSKLjrMamkM90LleHgDQ640XVIp6t7MkwnY9JzcHY-hE_ok1jtDN4WCgWB1FeXv37GHgq-FFzoZ9vlET-7tATO6yUHCnmLLQRveAkK4DZbcC5UqWpYXbB7OW85gbXQd9mFqBVIzfWCNevBh6FojwXu_YABJ-_yty9f14WLIeOnAwaHRewLt0lxtJMPRWdHO-DL--xOb3cZH5zfS_bx9asPV2_L6_dv3l2tr0tXKTmVKKpVteqwVb3uWm5BKF071dZ9C3wlhW40_aFVoDuAtrfgZCdtVYGj9TsrL9mLU9_9oR2xcximZHdmn_xo09FE682fmeA3Zog3BpRWknNq8OTUIObJm-z8hG5D6gK6yYAQUIu6IurpeUyKpDpPZvTZ4W5nA8ZDNrqhdUnKf0HgoEm5IPDxX-A2HlKgWxnR0BGqRkmC5AlyKeacsP8pTHAz22y25ofNZrbZcKCYqx79fpNfNWdfCXh-ApCcufGYZt2zlZ1Ps-wu-n8O-A6Sgrmz</recordid><startdate>20080610</startdate><enddate>20080610</enddate><creator>Sedivy, John M.</creator><creator>Banumathy, Gowrishankar</creator><creator>Adams, Peter D.</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20080610</creationdate><title>Aging by epigenetics—A consequence of chromatin damage?</title><author>Sedivy, John M. ; Banumathy, Gowrishankar ; Adams, Peter D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-e15757deb4f6db0a21468c4b8fb20731696a21ea426d22bfa2c3d3a552c001da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>AGING</topic><topic>Aging - genetics</topic><topic>Animals</topic><topic>Cancer</topic><topic>Cell senescence</topic><topic>Cellular biology</topic><topic>CHROMATIN</topic><topic>Chromatin - genetics</topic><topic>Chromatin - pathology</topic><topic>Chromatin Assembly and Disassembly</topic><topic>DNA DAMAGES</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Humans</topic><topic>Life expectancy</topic><topic>Longevity</topic><topic>NEOPLASMS</topic><topic>Progeria - pathology</topic><topic>STOCHASTIC PROCESSES</topic><topic>Yeasts - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedivy, John M.</creatorcontrib><creatorcontrib>Banumathy, Gowrishankar</creatorcontrib><creatorcontrib>Adams, Peter D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedivy, John M.</au><au>Banumathy, Gowrishankar</au><au>Adams, Peter D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging by epigenetics—A consequence of chromatin damage?</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>2008-06-10</date><risdate>2008</risdate><volume>314</volume><issue>9</issue><spage>1909</spage><epage>1917</epage><pages>1909-1917</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18423606</pmid><doi>10.1016/j.yexcr.2008.02.023</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4827 |
| ispartof | Experimental cell research, 2008-06, Vol.314 (9), p.1909-1917 |
| issn | 0014-4827 1090-2422 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2464300 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 60 APPLIED LIFE SCIENCES AGING Aging - genetics Animals Cancer Cell senescence Cellular biology CHROMATIN Chromatin - genetics Chromatin - pathology Chromatin Assembly and Disassembly DNA DAMAGES Epigenesis, Genetic Epigenetics Humans Life expectancy Longevity NEOPLASMS Progeria - pathology STOCHASTIC PROCESSES Yeasts - physiology |
| title | Aging by epigenetics—A consequence of chromatin damage? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T05%3A09%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aging%20by%20epigenetics%E2%80%94A%20consequence%20of%20chromatin%20damage?&rft.jtitle=Experimental%20cell%20research&rft.au=Sedivy,%20John%20M.&rft.date=2008-06-10&rft.volume=314&rft.issue=9&rft.spage=1909&rft.epage=1917&rft.pages=1909-1917&rft.issn=0014-4827&rft.eissn=1090-2422&rft_id=info:doi/10.1016/j.yexcr.2008.02.023&rft_dat=%3Cproquest_pubme%3E69207575%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=194685943&rft_id=info:pmid/18423606&rft_els_id=S0014482708001109&rfr_iscdi=true |