Aging by epigenetics—A consequence of chromatin damage?

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-de...

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Veröffentlicht in:	Experimental cell research 2008-06, Vol.314 (9), p.1909-1917
Hauptverfasser:	Sedivy, John M., Banumathy, Gowrishankar, Adams, Peter D.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AGING Aging - genetics Animals Cancer Cell senescence Cellular biology CHROMATIN Chromatin - genetics Chromatin - pathology Chromatin Assembly and Disassembly DNA DAMAGES Epigenesis, Genetic Epigenetics Humans Life expectancy Longevity NEOPLASMS Progeria - pathology STOCHASTIC PROCESSES Yeasts - physiology
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Beschreibung
Zusammenfassung:	Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/j.yexcr.2008.02.023