Psoriasis is associated with increased β-defensin genomic copy number

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Com...

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Veröffentlicht in:	Nature genetics 2008-01, Vol.40 (1), p.23-25
Hauptverfasser:	Zeeuwen, Patrick L J M, Hollox, Edward J, Rodijk-Olthuis, Diana, van de Kerkhof, Peter C M, Schalkwijk, Joost, Huffmeier, Ulrike, de Jongh, Gys, Heijer, Martin den, Armour, John A L, Traupe, Heiko, Palla, Raquel, Lascorz, Jesús, Reis, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics beta-Defensins - genetics Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Case-Control Studies Cellular proteins Chromosomes, Human, Pair 8 Diagnosis Gene Dosage Gene Function Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Human Genetics Humans Physiological aspects Polymorphism, Genetic Polymorphism, Single Nucleotide Psoriasis Psoriasis - genetics Risk factors
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Beschreibung
Zusammenfassung:	Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.2007.48