Alvaradoins E−N, Antitumor and Cytotoxic Anthracenone C-Glycosides from the Leaves of Alvaradoa haitiensis
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E−N (1−10), along with the known compound chrysophanol (11). The...
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Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.954-961 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E−N (1−10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure−activity relationships are suggested. The most potent compounds in the in vitro assays (1 and 2) were evaluated in vivo versus the P388 (murine lymphocytic leukemia) model, and alvaradoin E (1) showed antileukemic activity (125% T/C) at a dose of 0.2 mg kg-1 per injection when administered intraperitoneally. |
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ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np070005a |