A rush to judgment on Th17

Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role o...

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Veröffentlicht in:	The Journal of experimental medicine 2008-07, Vol.205 (7), p.1517-1522
1. Verfasser:	Steinman, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies - pharmacology Antigens - immunology Autoimmunity - drug effects Autoimmunity - genetics Cell Line Central Nervous System - immunology Central Nervous System - pathology Chemokines, CXC - immunology Commentaries Dendritic Cells - immunology Disease Susceptibility Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Eye - immunology Eye - pathology Female Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans Inflammation Mediators - immunology Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-12 Subunit p35 - genetics Interleukin-12 Subunit p35 - immunology Interleukin-17 - antagonists & inhibitors Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-23 - genetics Interleukin-23 - immunology Lymphocyte Activation - drug effects Macrophages - immunology Macrophages - pathology Mice Mice, Inbred C57BL Mice, Knockout Models, Immunological Myelin Sheath - immunology Myelin Sheath - pathology Neutralization Tests Neutrophils - immunology Neutrophils - pathology Nitric Oxide Synthase Type II - immunology Paralysis - immunology Paralysis - pathology Proteins - antagonists & inhibitors Proteins - immunology Th1 Cells - immunology Up-Regulation - genetics Up-Regulation - immunology Uveitis - genetics Uveitis - immunology Uveitis - pathology Uveitis - prevention & control
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Beschreibung
Zusammenfassung:	Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role of Th17 cytokines as the central mediators of pathological tissue damage seems to require clarification.
ISSN:	0022-1007 1540-9538 1892-1007
DOI:	10.1084/jem.20072066