The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands

The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands

Background The impact of age and adjuvant therapy on contralateral breast cancer (CBC) risk and prognostic significance of CBC were evaluated. Patients and Methods In 45,229 surgically treated stage I–IIIA patients diagnosed in the Netherlands between 1989 and 2002 CBC risk was quantified using stan...

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Veröffentlicht in:Breast cancer research and treatment 2008-07, Vol.110 (1), p.189-197
Hauptverfasser: Schaapveld, Michael, Visser, Otto, Louwman, W. J., Willemse, Pax H. B., de Vries, Elisabeth G. E., van der Graaf, Winette T. A., Otter, Renée, Coebergh, Jan Willem W., van Leeuwen, Flora E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - etiology
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Cancer research
Cancer therapies
Chemotherapy
Combined Modality Therapy
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Hormone replacement therapy
Humans
Incidence
Mammary gland diseases
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasms, Multiple Primary - etiology
Neoplasms, Second Primary - etiology
Neoplasms, Second Primary - mortality
Oncology
Prognosis
Risk factors
Tumors
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Zusammenfassung:Background The impact of age and adjuvant therapy on contralateral breast cancer (CBC) risk and prognostic significance of CBC were evaluated. Patients and Methods In 45,229 surgically treated stage I–IIIA patients diagnosed in the Netherlands between 1989 and 2002 CBC risk was quantified using standardised incidence ratios (SIRs), cumulative incidence and Cox regression analysis, adjusted for competing risks. Results Median follow-up was 5.8 years, in which 624 CBC occurred
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-007-9709-2