Regulatory T cells and tumour immunity - observations in mice and men

An enormous body of work supports a role for CD4⁺ CD25⁺ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies...

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Veröffentlicht in:	Immunology 2008-02, Vol.123 (2), p.157-163
Hauptverfasser:	Gallimore, Awen, Godkin, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer Forkhead Transcription Factors - blood Humans immune surveillance Immune Tolerance Immunotherapy - methods Mice neoplasms Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Neoplasms, Experimental - immunology regulation Review T-Lymphocytes, Regulatory - immunology
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Beschreibung
Zusammenfassung:	An enormous body of work supports a role for CD4⁺ CD25⁺ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.
ISSN:	0019-2805 1365-2567 1365-2567
DOI:	10.1111/j.1365-2567.2007.02748.x