Early onset life-threatening myelosuppression after low dose of intravesical thiotepa

Intravesical instillation of thiotepa is a popular treatment for localized bladder carcinoma. The drug can enter the systemic circulation, and such absorption may be enhanced by extensive tumour infiltration or by a recent tumour resection. A case is reported of early onset life-threatening pancytop...

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Veröffentlicht in:	Postgraduate medical journal 1982-06, Vol.58 (680), p.380-381
Hauptverfasser:	Agnelli, Giancarlo, Gresele, Paolo, de Cunto, Maria, del Favero, Albano
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Papillary - drug therapy Clinical Reports Humans Male Pancytopenia - chemically induced Thiotepa - administration & dosage Thiotepa - adverse effects Urinary Bladder Neoplasms - drug therapy
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Beschreibung
Zusammenfassung:	Intravesical instillation of thiotepa is a popular treatment for localized bladder carcinoma. The drug can enter the systemic circulation, and such absorption may be enhanced by extensive tumour infiltration or by a recent tumour resection. A case is reported of early onset life-threatening pancytopenia following an unusually low dose of the drug in a patient who had undergone a recent tumour resection.
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.58.680.380