Twenty-Four Hour Hypothermic Machine Perfusion Preservation of Porcine Pancreas Facilitates Processing for Islet Isolation

Abstract Procurement of donor pancreata for islet isolation and transplantation is not yet widely practiced due to concerns about the impact of postmortem ischemia on functional islet yields. Perfusion/preservation technology may help to circumvent ischemic injury as applied in this study of porcine...

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Veröffentlicht in:	Transplantation proceedings 2008-03, Vol.40 (2), p.480-482
Hauptverfasser:	Taylor, M.J, Baicu, S, Leman, B, Greene, E, Vazquez, A, Brassil, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - analysis Animals Biological and medical sciences Cell Separation - methods Fundamental and applied biological sciences. Psychology Fundamental immunology Hypothermia, Induced Insulin - analysis Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Medical sciences Organ Preservation - methods Organ Size Pancreas - anatomy & histology Pancreas - metabolism Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Tissue, organ and graft immunology
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Zusammenfassung:	Abstract Procurement of donor pancreata for islet isolation and transplantation is not yet widely practiced due to concerns about the impact of postmortem ischemia on functional islet yields. Perfusion/preservation technology may help to circumvent ischemic injury as applied in this study of porcine pancreata prior to islet isolation. Pancreata harvested from adult pigs were assigned to 1 of 3 preservation treatment groups: G1, fresh controls, processed immediately with minimum cold ischemia (
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2008.01.004