Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants
T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cel...
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| Veröffentlicht in: | The Journal of experimental medicine 2008-06, Vol.205 (6), p.1331-1342 |
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| container_title | The Journal of experimental medicine |
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| creator | Weller, Sandra Mamani-Matsuda, Maria Picard, Capucine Cordier, Corinne Lecoeuche, Damiana Gauthier, Frédéric Weill, Jean-Claude Reynaud, Claude-Agnès |
| description | T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children |
| doi_str_mv | 10.1084/jem.20071555 |
| format | Article |
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We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM(+)IgD(+)CD27(+) B cells in the spleen and blood displays no sign of antigen-driven activation and expansion on H-CDR3 spectratyping, despite the many antigenic challenges provided by childhood vaccinations. This repertoire differed markedly from those of switched B cells and splenic germinal center B cells, even at the early stage of differentiation associated with mu heavy chain expression. These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20071555</identifier><identifier>PMID: 18519648</identifier><language>eng</language><publisher>United States: Rockefeller University Press</publisher><subject>Antigens, CD ; Antigens, CD - immunology ; Antigens, CD27 ; B-Lymphocyte Subsets ; B-Lymphocyte Subsets - immunology ; B-Lymphocytes ; B-Lymphocytes - immunology ; Gene Rearrangement ; Genetic Variation ; Humans ; Immunoglobulin D ; Immunoglobulin D - immunology ; Immunoglobulin M ; Immunoglobulin M - immunology ; Immunoglobulin mu-Chains ; Immunoglobulin mu-Chains - immunology ; Immunoglobulin Variable Region ; Immunoglobulin Variable Region - genetics ; Immunologic Memory ; Immunology ; Infant ; Life Sciences ; Lymphocyte Activation ; Spleen ; Spleen - immunology ; T-Lymphocytes ; T-Lymphocytes - immunology ; Transcription, Genetic ; Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology ; Variation (Genetics)</subject><ispartof>The Journal of experimental medicine, 2008-06, Vol.205 (6), p.1331-1342</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2008 Weller et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-6fe339ac02de58d45f4d529506d5b400386210b264b4786ea8430843a7a5044b3</citedby><cites>FETCH-LOGICAL-c349t-6fe339ac02de58d45f4d529506d5b400386210b264b4786ea8430843a7a5044b3</cites><orcidid>0000-0001-8788-5056</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18519648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00331378$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Weller, Sandra</creatorcontrib><creatorcontrib>Mamani-Matsuda, Maria</creatorcontrib><creatorcontrib>Picard, Capucine</creatorcontrib><creatorcontrib>Cordier, Corinne</creatorcontrib><creatorcontrib>Lecoeuche, Damiana</creatorcontrib><creatorcontrib>Gauthier, Frédéric</creatorcontrib><creatorcontrib>Weill, Jean-Claude</creatorcontrib><creatorcontrib>Reynaud, Claude-Agnès</creatorcontrib><title>Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM(+)IgD(+)CD27(+) B cells in the spleen and blood displays no sign of antigen-driven activation and expansion on H-CDR3 spectratyping, despite the many antigenic challenges provided by childhood vaccinations. This repertoire differed markedly from those of switched B cells and splenic germinal center B cells, even at the early stage of differentiation associated with mu heavy chain expression. These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses.</description><subject>Antigens, CD</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD27</subject><subject>B-Lymphocyte Subsets</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Gene Rearrangement</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Immunoglobulin D</subject><subject>Immunoglobulin D - immunology</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunoglobulin mu-Chains</subject><subject>Immunoglobulin mu-Chains - immunology</subject><subject>Immunoglobulin Variable Region</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Immunologic Memory</subject><subject>Immunology</subject><subject>Infant</subject><subject>Life Sciences</subject><subject>Lymphocyte Activation</subject><subject>Spleen</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Transcription, Genetic</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology</subject><subject>Variation (Genetics)</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EotvCjTPyicuSMv5KnAtS2QKttIgDcLacZLLrkthbO7sSf4DfXYcuFLjYGs0z73y8hLxgcM5Ayzc3OJ5zgIoppR6RBVMSiloJ_ZgsADgvWM6dkNOUbgCYlKp8Sk6YVqwupV6Qn1_CaCfX0s4dMCbXuzaHwVPn6bRFapuEvkUaemr95Dboiy5m1NOIaRd8wkRd-oVu7TCMNn6f2Tm-3nxa5udySVeXvFrSd7TFYch1O4xTcBHnHs73WTc9I096OyR8fvzPyLcP77-uror154_Xq4t10QpZT0XZoxC1bYF3qHQnVS87xWsFZacaCSB0yRk0vJSNrHSJVkuRbyRsZRVI2Ygz8vZed7dvRuxa9FO0g9lFlyf_YYJ15t-Md1uzCQfDJRMgWBZ4fS-w_a_s6mJtXD5HHE2eI5OVPsz4q2O_GG73mCYzujSfwXoM-2QqVioFmj_otjGkFLH_I87AzD6b7LP57XPGX_69xwN8NFbcAYFhox8</recordid><startdate>20080609</startdate><enddate>20080609</enddate><creator>Weller, Sandra</creator><creator>Mamani-Matsuda, Maria</creator><creator>Picard, Capucine</creator><creator>Cordier, Corinne</creator><creator>Lecoeuche, Damiana</creator><creator>Gauthier, Frédéric</creator><creator>Weill, Jean-Claude</creator><creator>Reynaud, Claude-Agnès</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8788-5056</orcidid></search><sort><creationdate>20080609</creationdate><title>Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants</title><author>Weller, Sandra ; Mamani-Matsuda, Maria ; Picard, Capucine ; Cordier, Corinne ; Lecoeuche, Damiana ; Gauthier, Frédéric ; Weill, Jean-Claude ; Reynaud, Claude-Agnès</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-6fe339ac02de58d45f4d529506d5b400386210b264b4786ea8430843a7a5044b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antigens, CD</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD27</topic><topic>B-Lymphocyte Subsets</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Gene Rearrangement</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Immunoglobulin D</topic><topic>Immunoglobulin D - immunology</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunoglobulin mu-Chains</topic><topic>Immunoglobulin mu-Chains - immunology</topic><topic>Immunoglobulin Variable Region</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Immunologic Memory</topic><topic>Immunology</topic><topic>Infant</topic><topic>Life Sciences</topic><topic>Lymphocyte Activation</topic><topic>Spleen</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Transcription, Genetic</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology</topic><topic>Variation (Genetics)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weller, Sandra</creatorcontrib><creatorcontrib>Mamani-Matsuda, Maria</creatorcontrib><creatorcontrib>Picard, Capucine</creatorcontrib><creatorcontrib>Cordier, Corinne</creatorcontrib><creatorcontrib>Lecoeuche, Damiana</creatorcontrib><creatorcontrib>Gauthier, Frédéric</creatorcontrib><creatorcontrib>Weill, Jean-Claude</creatorcontrib><creatorcontrib>Reynaud, Claude-Agnès</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weller, Sandra</au><au>Mamani-Matsuda, Maria</au><au>Picard, Capucine</au><au>Cordier, Corinne</au><au>Lecoeuche, Damiana</au><au>Gauthier, Frédéric</au><au>Weill, Jean-Claude</au><au>Reynaud, Claude-Agnès</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2008-06-09</date><risdate>2008</risdate><volume>205</volume><issue>6</issue><spage>1331</spage><epage>1342</epage><pages>1331-1342</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children <2 yr of age, with the aim of determining whether these two subsets are developmentally related. We show that the repertoire of IgM(+)IgD(+)CD27(+) B cells in the spleen and blood displays no sign of antigen-driven activation and expansion on H-CDR3 spectratyping, despite the many antigenic challenges provided by childhood vaccinations. This repertoire differed markedly from those of switched B cells and splenic germinal center B cells, even at the early stage of differentiation associated with mu heavy chain expression. These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>18519648</pmid><doi>10.1084/jem.20071555</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8788-5056</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens, CD Antigens, CD - immunology Antigens, CD27 B-Lymphocyte Subsets B-Lymphocyte Subsets - immunology B-Lymphocytes B-Lymphocytes - immunology Gene Rearrangement Genetic Variation Humans Immunoglobulin D Immunoglobulin D - immunology Immunoglobulin M Immunoglobulin M - immunology Immunoglobulin mu-Chains Immunoglobulin mu-Chains - immunology Immunoglobulin Variable Region Immunoglobulin Variable Region - genetics Immunologic Memory Immunology Infant Life Sciences Lymphocyte Activation Spleen Spleen - immunology T-Lymphocytes T-Lymphocytes - immunology Transcription, Genetic Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology Variation (Genetics) |
| title | Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants |
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