Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants

T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cel...

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Veröffentlicht in:	The Journal of experimental medicine 2008-06, Vol.205 (6), p.1331-1342
Hauptverfasser:	Weller, Sandra, Mamani-Matsuda, Maria, Picard, Capucine, Cordier, Corinne, Lecoeuche, Damiana, Gauthier, Frédéric, Weill, Jean-Claude, Reynaud, Claude-Agnès
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Antigens, CD - immunology Antigens, CD27 B-Lymphocyte Subsets B-Lymphocyte Subsets - immunology B-Lymphocytes B-Lymphocytes - immunology Gene Rearrangement Genetic Variation Humans Immunoglobulin D Immunoglobulin D - immunology Immunoglobulin M Immunoglobulin M - immunology Immunoglobulin mu-Chains Immunoglobulin mu-Chains - immunology Immunoglobulin Variable Region Immunoglobulin Variable Region - genetics Immunologic Memory Immunology Infant Life Sciences Lymphocyte Activation Spleen Spleen - immunology T-Lymphocytes T-Lymphocytes - immunology Transcription, Genetic Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology Variation (Genetics)
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Zusammenfassung:	T cell-dependent immune responses develop soon after birth, whereas it takes 2 yr for humans to develop T cell-independent responses. We used this dissociation to analyze the repertoire diversification of IgM(+)IgD(+)CD27(+) B cells (also known as "IgM memory" B cells), comparing these cells with switched B cells in children
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.20071555