MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not

The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2 −1306T and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-...

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Veröffentlicht in:	British journal of cancer 2008-06, Vol.98 (11), p.1820-1823
Hauptverfasser:	Langers, A M J, Sier, C F M, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Lamers, C B H W, Hommes, D W, Verspaget, H W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Colorectal cancer Colorectal Neoplasms - enzymology Colorectal Neoplasms - mortality Drug Resistance Epidemiology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Genotype Hepatology Humans Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - genetics Medical prognosis Medical research Medical sciences Molecular Medicine Oncology Phenotype Polymorphism Polymorphism, Single Nucleotide Prognosis Promoter Regions, Genetic Proteins Short Communication Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival analysis Tumors
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Zusammenfassung:	The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2 −1306T and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9 −1562C>T was not. Tumour MMP levels were not determined by their SNP genotypes.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6604380