The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer

The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein ent...

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Veröffentlicht in:	British journal of cancer 2004-10, Vol.91 (7), p.1236-1238
Hauptverfasser:	BROMWICH, E, MCMILLAN, D. C, LAMB, G. W. A, VASEY, P. A, AITCHISON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - therapeutic use Biological and medical sciences C-Reactive Protein - analysis Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Clinical Female Health Status Humans Inflammation Interferon-alpha - therapeutic use Kidney Neoplasms - drug therapy Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Predictive Value of Tests Prognosis Survival Analysis Treatment Outcome Tumors Tumors of the urinary system
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Zusammenfassung:	The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates, only C-reactive protein was a significant independent predictor of survival (HR 2.03, 95% CI 1.09-3.80, P=0.026).
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6602152