Nephrotic syndrome in adults

Hull and Goldsmith discuss nephrotic syndrome in adults. The nephrotic syndrome is one of the best known presentations of adult or pediatric kidney disease. It can present in diverse ways in multiple healthcare settings and has important complications. Investigating and managing the syndrome is made more challenging by the lack of a guiding evidence base, but strategies derived from expert consensus are available for its initial management. All patients presenting with nephrotic syndrome should be discussed with local kidney specialists before embarking on further investigations and management. Large randomized trials in the management of the nephrotic syndrome, and in glomerular disease in general, are urgently needed to achieve further progress.