New molecular pathways in angiogenesis

Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-can...

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Veröffentlicht in:	British journal of cancer 2003-07, Vol.89 (2), p.228-231
Hauptverfasser:	SUKKUVAB, D. C, BICKNELL, Abd R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biological and medical sciences Blood vessels Cancer research Endothelium Ephrins - pharmacology Hedgehog Proteins Humans Hypoxia Kinases Ligands Medical research Medical sciences Membrane Proteins - pharmacology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - genetics Neoplasms - physiopathology Neovascularization, Pathologic - genetics Receptors, Eph Family - physiology Receptors, Notch Review Signal Transduction Trans-Activators - pharmacology Tumors Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6601107