Identification of New Quantitative Trait Loci (Other Than the PRNP Gene) Modulating the Scrapie Incubation Period in Sheep

Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detect...

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Veröffentlicht in:	Genetics (Austin) 2008-05, Vol.179 (1), p.723-726
Hauptverfasser:	Moreno, C.R, Cosseddu, G.M, Schibler, L, Roig, A, Moazami-Goudarzi, K, Andreoletti, O, Eychenne, F, Lajous, D, Schelcher, F, Cribiu, E.P, Laurent, P, Vaiman, D, Elsen, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial insemination Chromosomes disease resistance Genes Genetic Predisposition to Disease - genetics Genetics Immunity, Innate - genetics Life Sciences Likelihood Functions pathogenesis Prions quantitative trait loci Quantitative Trait Loci - genetics scrapie Scrapie - genetics Sheep Spongiform encephalopathies Standard deviation Survival Analysis Time Factors Variance analysis
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Zusammenfassung:	Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.
ISSN:	0016-6731 1943-2631 1943-2631
DOI:	10.1534/genetics.108.088146