Telomere length and risk of Parkinson's disease

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case‐control study (96 cases and 172 age‐matched controls) nested within the Health Professionals Follow‐up Study. Relative ratio of telomere repeat copy number to single‐gene copy number in pe...

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Veröffentlicht in:	Movement disorders 2008-01, Vol.23 (2), p.302-305
Hauptverfasser:	Wang, Hao, Chen, Honglei, Gao, Xiang, McGrath, Monica, Deer, Dwayne, De Vivo, Immaculata, Schwarzschild, Michael A., Ascherio, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Follow-Up Studies Humans Male Medical sciences Middle Aged nested case-control study Neurology Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease relative risk Retrospective Studies Risk Factors Telomere - pathology Telomere - ultrastructure telomere length
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Zusammenfassung:	We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case‐control study (96 cases and 172 age‐matched controls) nested within the Health Professionals Follow‐up Study. Relative ratio of telomere repeat copy number to single‐gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12–0.90). Our results suggest that, contrary to telomere attrition observed in several aging‐related diseases, shorter telomeres are not associated with an increased risk of PD. © 2007 Movement Disorder Society
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.21867