Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic ef...
Gespeichert in:
| Veröffentlicht in: | British journal of cancer 2002-02, Vol.86 (3), p.485-489 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 489 |
|---|---|
| container_issue | 3 |
| container_start_page | 485 |
| container_title | British journal of cancer |
| container_volume | 86 |
| creator | Meczes, E L Pearson, A D J Austin, C A Tilby, M J |
| description | The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. |
| doi_str_mv | 10.1038/sj.bjc.6600060 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2375204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>899135030</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-885ef81265c8f607caaa584110b4af06a158a29180b8a45301525b7cf1f3c8a73</originalsourceid><addsrcrecordid>eNp1kUFv1DAQhS1ERZfClRsoQqo4ZTu214lzqYSqApUqcQDO1sSZtIkSO9gJEv8erzZ0oVJPlv2-Gc-bx9gbDlsOUl_Eflv3dlsUAFDAM7bhSoqca1E-Z5v0VuZQCThlL2Ps07UCXb5gp5zrUpW82rD6m72nZhkob2gi15Cbs0Bx8i5S5tvM0RJ8PWCc_YiZpWHIhs5RzGafWT_WncO5S_CepdlPPnYNZeiazHZxGpLoXrGTFodIr9fzjP34dP396kt--_XzzdXH29wqKOZca0Wt5qJQVrcFlBYRld5xDvUOWyiQK42i4hpqjTslgSuh6tK2vJVWYynP2OWh77TUIzU2WQk4mCl0I4bfxmNn_ldcd2_u_C8jZKkE7FKDD2uD4H8uFGczdnFvGR35JRpdVVwqkJDI94_I3i_BJXdGiKrSXOsqQdsDZIOPMVD7MAoHsw_PxN6k8MwaXip496-BI76mlYDzFcBocWgDurTlIye1LDjfb-LiwMUkuTsKx_Ge_PrtoSLFuQR6aPlX_wPPkL37</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229981889</pqid></control><display><type>article</type><title>Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Meczes, E L ; Pearson, A D J ; Austin, C A ; Tilby, M J</creator><creatorcontrib>Meczes, E L ; Pearson, A D J ; Austin, C A ; Tilby, M J</creatorcontrib><description>The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6600060</identifier><identifier>PMID: 11875719</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - toxicity ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Division - drug effects ; Cisplatin - toxicity ; Drug dosages ; Drug Resistance ; Drug Synergism ; Epidemiology ; Etoposide - toxicity ; Experimental Therapeutics ; General aspects ; Humans ; Medical research ; Medical sciences ; Molecular Medicine ; Neuroblastoma ; Oncology ; Pharmacology. Drug treatments ; Schedules ; Time Factors ; Tumor Cells, Cultured</subject><ispartof>British journal of cancer, 2002-02, Vol.86 (3), p.485-489</ispartof><rights>The Author(s) 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 The Cancer Research Campaign</rights><rights>Copyright Nature Publishing Group Feb 1, 2002</rights><rights>Copyright © 2002 The Cancer Research Campaign 2002 The Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-885ef81265c8f607caaa584110b4af06a158a29180b8a45301525b7cf1f3c8a73</citedby><cites>FETCH-LOGICAL-c506t-885ef81265c8f607caaa584110b4af06a158a29180b8a45301525b7cf1f3c8a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375204/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375204/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2727,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13836117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11875719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meczes, E L</creatorcontrib><creatorcontrib>Pearson, A D J</creatorcontrib><creatorcontrib>Austin, C A</creatorcontrib><creatorcontrib>Tilby, M J</creatorcontrib><title>Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - toxicity</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Division - drug effects</subject><subject>Cisplatin - toxicity</subject><subject>Drug dosages</subject><subject>Drug Resistance</subject><subject>Drug Synergism</subject><subject>Epidemiology</subject><subject>Etoposide - toxicity</subject><subject>Experimental Therapeutics</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Neuroblastoma</subject><subject>Oncology</subject><subject>Pharmacology. Drug treatments</subject><subject>Schedules</subject><subject>Time Factors</subject><subject>Tumor Cells, Cultured</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFv1DAQhS1ERZfClRsoQqo4ZTu214lzqYSqApUqcQDO1sSZtIkSO9gJEv8erzZ0oVJPlv2-Gc-bx9gbDlsOUl_Eflv3dlsUAFDAM7bhSoqca1E-Z5v0VuZQCThlL2Ps07UCXb5gp5zrUpW82rD6m72nZhkob2gi15Cbs0Bx8i5S5tvM0RJ8PWCc_YiZpWHIhs5RzGafWT_WncO5S_CepdlPPnYNZeiazHZxGpLoXrGTFodIr9fzjP34dP396kt--_XzzdXH29wqKOZca0Wt5qJQVrcFlBYRld5xDvUOWyiQK42i4hpqjTslgSuh6tK2vJVWYynP2OWh77TUIzU2WQk4mCl0I4bfxmNn_ldcd2_u_C8jZKkE7FKDD2uD4H8uFGczdnFvGR35JRpdVVwqkJDI94_I3i_BJXdGiKrSXOsqQdsDZIOPMVD7MAoHsw_PxN6k8MwaXip496-BI76mlYDzFcBocWgDurTlIye1LDjfb-LiwMUkuTsKx_Ge_PrtoSLFuQR6aPlX_wPPkL37</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Meczes, E L</creator><creator>Pearson, A D J</creator><creator>Austin, C A</creator><creator>Tilby, M J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20020201</creationdate><title>Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin</title><author>Meczes, E L ; Pearson, A D J ; Austin, C A ; Tilby, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-885ef81265c8f607caaa584110b4af06a158a29180b8a45301525b7cf1f3c8a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - toxicity</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Division - drug effects</topic><topic>Cisplatin - toxicity</topic><topic>Drug dosages</topic><topic>Drug Resistance</topic><topic>Drug Synergism</topic><topic>Epidemiology</topic><topic>Etoposide - toxicity</topic><topic>Experimental Therapeutics</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Molecular Medicine</topic><topic>Neuroblastoma</topic><topic>Oncology</topic><topic>Pharmacology. Drug treatments</topic><topic>Schedules</topic><topic>Time Factors</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meczes, E L</creatorcontrib><creatorcontrib>Pearson, A D J</creatorcontrib><creatorcontrib>Austin, C A</creatorcontrib><creatorcontrib>Tilby, M J</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meczes, E L</au><au>Pearson, A D J</au><au>Austin, C A</au><au>Tilby, M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>86</volume><issue>3</issue><spage>485</spage><epage>489</epage><pages>485-489</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11875719</pmid><doi>10.1038/sj.bjc.6600060</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2002-02, Vol.86 (3), p.485-489 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2375204 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - toxicity Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Division - drug effects Cisplatin - toxicity Drug dosages Drug Resistance Drug Synergism Epidemiology Etoposide - toxicity Experimental Therapeutics General aspects Humans Medical research Medical sciences Molecular Medicine Neuroblastoma Oncology Pharmacology. Drug treatments Schedules Time Factors Tumor Cells, Cultured |
| title | Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A02%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Schedule-dependent%20response%20of%20neuroblastoma%20cell%20lines%20to%20combinations%20of%20etoposide%20and%20cisplatin&rft.jtitle=British%20journal%20of%20cancer&rft.au=Meczes,%20E%20L&rft.date=2002-02-01&rft.volume=86&rft.issue=3&rft.spage=485&rft.epage=489&rft.pages=485-489&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/sj.bjc.6600060&rft_dat=%3Cproquest_pubme%3E899135030%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=229981889&rft_id=info:pmid/11875719&rfr_iscdi=true |