Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin

The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic ef...

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Veröffentlicht in:	British journal of cancer 2002-02, Vol.86 (3), p.485-489
Hauptverfasser:	Meczes, E L, Pearson, A D J, Austin, C A, Tilby, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - toxicity Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Division - drug effects Cisplatin - toxicity Drug dosages Drug Resistance Drug Synergism Epidemiology Etoposide - toxicity Experimental Therapeutics General aspects Humans Medical research Medical sciences Molecular Medicine Neuroblastoma Oncology Pharmacology. Drug treatments Schedules Time Factors Tumor Cells, Cultured
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Zusammenfassung:	The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6600060