A polymorphism in the CYP17 gene is associated with male breast cancer

The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.

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Bibliographische Detailangaben
Veröffentlicht in:	British Journal of Cancer 1999-09, Vol.81 (1), p.141-143
Hauptverfasser:	YOUNG, I. E, KURIAN, K. M, ANNINK, C, KUNKIER, I. H, ANDERSON, V. A, COHEN, B. B, HOOPER, M. L, WYLLIE, A. H, STEEL, C. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Androgens - blood Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms, Male - blood Breast Neoplasms, Male - enzymology Breast Neoplasms, Male - genetics Case-Control Studies Estrogens - blood Female Genotype Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Middle Aged Polymorphism, Genetic Short Communication Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Tumors
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Beschreibung
Zusammenfassung:	The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.
ISSN:	0007-0920 1476-5381 1532-1827
DOI:	10.1038/sj.bjc.6690663