The epidemiology of conjunctival squamous cell carcinoma in Uganda

As part of a larger investigation of cancer in Uganda, we conducted a case–control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in Kampala. Participants were interviewed about social and lifestyle factors and had blood tested for antibodies to HIV, KSHV and HPV-16,...

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Veröffentlicht in:	British journal of cancer 2002-07, Vol.87 (3), p.301-308
Hauptverfasser:	Newton, R, Ziegler, J, Ateenyi-Agaba, C, Bousarghin, L, Casabonne, D, Beral, V, Mbidde, E, Carpenter, L, Reeves, G, Parkin, D M, Wabinga, H, Mbulaiteye, S, Jaffe, H, Bourboulia, D, Boshoff, C, Touzé, A, Coursaget, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies Antibodies, Viral - analysis Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - etiology Conjunctival Neoplasms - epidemiology Conjunctival Neoplasms - etiology Drug Resistance Epidemiology Female Herpes viruses Herpesvirus 8, Human - immunology HIV HIV Infections - complications Human immunodeficiency virus Human papillomavirus Humans Infections Kaposi's sarcoma-associated herpesvirus Kaposis sarcoma Male Medical research Medical sciences Middle Aged Molecular Medicine Oncology Ophthalmology Papillomaviridae - immunology Risk Factors Sunlight - adverse effects Tropical medicine Tumors Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Uganda - epidemiology
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Beschreibung
Zusammenfassung:	As part of a larger investigation of cancer in Uganda, we conducted a case–control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in Kampala. Participants were interviewed about social and lifestyle factors and had blood tested for antibodies to HIV, KSHV and HPV-16, -18 and -45. The odds of each factor among 60 people with conjunctival cancer was compared to that among 1214 controls with other cancer sites or types, using odds ratios, estimated with unconditional logistic regression. Conjunctival cancer was associated with HIV infection (OR 10.1, 95% confidence intervals [CI] 5.2–19.4; P
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6600451