Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase

Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml –1 ) in 1% but not in 21% oxygen induced a remarkable increase in NO...

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Veröffentlicht in:	British journal of cancer 2001-04, Vol.84 (8), p.1122-1125
Hauptverfasser:	Berge, D L Van den, Ridder, M De, Verovski, V N, Janssens, M Y, Monsaert, C, Storme, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Northern Blotting, Western Cancer Research Cell Survival - drug effects Cell Survival - radiation effects Cytokines Cytokines - pharmacology Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Resistance Enzymes Epidemiology Gene Expression Regulation, Enzymologic - drug effects Hypoxia Interferon-gamma - pharmacology Interleukin-1 - pharmacology Medical research Medical sciences Molecular Medicine Nitric oxide Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitrites - metabolism Oncology Oxygen - pharmacology Proteins Radiation therapy and radiosensitizing agent Regular regular-article RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - radiation effects Tumors
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Zusammenfassung:	Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml –1 ) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1054/bjoc.2000.1719